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| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (293 aa) |
| | RAD51C | RAD51 paralog C. (368 aa) |
| | H2ZS39_LATCH | Histone H2B; Belongs to the histone H2B family. (135 aa) |
| | H2ZS42_LATCH | AAA_23 domain-containing protein. (88 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (447 aa) |
| | H2ZVL4_LATCH | Histone domain-containing protein; Belongs to the histone H2B family. (90 aa) |
| | TDRD3 | Tudor domain containing 3. (746 aa) |
| | H2ZWI5_LATCH | Uncharacterized protein. (1469 aa) |
| | PALB2 | PALB2_WD40 domain-containing protein. (874 aa) |
| | UBE2V2 | Ubiquitin conjugating enzyme E2 V2. (55 aa) |
| | H2ZZP4_LATCH | Histone H2B; Belongs to the histone H2B family. (138 aa) |
| | CDCA7 | Cell division cycle associated 7. (405 aa) |
| | RNF169 | Ring finger protein 169. (684 aa) |
| | RFC1 | Replication factor C subunit 1. (1152 aa) |
| | LOC102346166 | Ubiquitin-like domain-containing protein. (95 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (282 aa) |
| | LOC102350907 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa) |
| | H3A2S8_LATCH | Histone H2B; Belongs to the histone H2B family. (138 aa) |
| | H3A427_LATCH | Histone H2B; Belongs to the histone H2B family. (137 aa) |
| | LOC102361505 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H3A4B2_LATCH | Reverse transcriptase domain-containing protein. (787 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (413 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (710 aa) |
| | H3A560_LATCH | RAD50 homolog, double strand break repair protein. (1193 aa) |
| | H3A5E7_LATCH | Histone H2B; Belongs to the histone H2B family. (130 aa) |
| | H4C11 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | H3A5V3_LATCH | RecQ helicase-like 4. (1456 aa) |
| | ATM | ATM serine/threonine kinase. (2375 aa) |
| | ANKRD12 | Ankyrin repeat domain 12. (2105 aa) |
| | POLK | DNA polymerase kappa. (873 aa) |
| | H3A8A9_LATCH | Uncharacterized protein. (271 aa) |
| | H3A8P8_LATCH | DUF4502 domain-containing protein. (165 aa) |
| | RMI1 | RecQ mediated genome instability 1. (616 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1542 aa) |
| | LOC102355250 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (264 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa) |
| | BRCA1 | BRCA1 DNA repair associated. (1873 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (225 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (542 aa) |
| | H3ABS6_LATCH | Uncharacterized protein. (443 aa) |
| | BLM | BLM RecQ like helicase. (1450 aa) |
| | RMI2 | RecQ mediated genome instability 2. (158 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (224 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (281 aa) |
| | H3AE13_LATCH | Uncharacterized protein. (380 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (495 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (735 aa) |
| | UBE2N | Ubiquitin-conjugating enzyme E2Na; Belongs to the ubiquitin-conjugating enzyme family. (159 aa) |
| | H3AF58_LATCH | Uncharacterized protein. (251 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (433 aa) |
| | H3AFK9_LATCH | RING-type domain-containing protein. (482 aa) |
| | RPS27A | Ribosomal protein S27a. (156 aa) |
| | LOC102347040 | Ubiquitin-conjugating enzyme E2Ia; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | LOC102367189 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (342 aa) |
| | H3AGP4_LATCH | Tower domain-containing protein. (1245 aa) |
| | SIRT6 | Sirtuin 6. (375 aa) |
| | KXD1 | Ubiquitin-like domain-containing protein. (231 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (772 aa) |
| | H3AIY4_LATCH | Uncharacterized protein. (161 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (2149 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (358 aa) |
| | H3AK44_LATCH | Histone domain-containing protein; Belongs to the histone H2B family. (105 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (999 aa) |
| | SIRT7 | Sirtuin 7. (413 aa) |
| | H3AKN8_LATCH | Uncharacterized protein. (129 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | POLD3 | Uncharacterized protein. (373 aa) |
| | H3ALL9_LATCH | Uncharacterized protein. (251 aa) |
| | RAD9A | Uncharacterized protein. (273 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (323 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2654 aa) |
| | RFC3 | Replication factor C subunit 3. (237 aa) |
| | ANKRD11 | Ankyrin repeat domain 11. (2717 aa) |
| | H3APN8_LATCH | Reverse transcriptase domain-containing protein. (202 aa) |
| | H2BE1 | Histone H2B; Belongs to the histone H2B family. (122 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (748 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1348 aa) |
| | POLD4 | Uncharacterized protein. (122 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (370 aa) |
| | POLH | DNA polymerase eta. (729 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (412 aa) |
| | PWWP2A | PWWP domain containing 2A. (843 aa) |
| | H3AWE1_LATCH | Uncharacterized protein. (135 aa) |
| | MUS81 | Uncharacterized protein. (421 aa) |
| | H3AYY3_LATCH | Uncharacterized protein. (223 aa) |
| | H3AZT0_LATCH | Uncharacterized protein. (114 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (299 aa) |
| | SLX4 | BTB domain-containing protein. (1393 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (469 aa) |
| | PPP4R2 | Protein phosphatase 4, regulatory subunit 2b. (410 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (925 aa) |
| | H3B1Z1_LATCH | Uncharacterized protein. (352 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (899 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (291 aa) |
| | SPIDR | DUF4503 domain-containing protein. (397 aa) |
| | POLD1 | DNA polymerase. (1103 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1063 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (531 aa) |
| | CHEK1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (475 aa) |
| | H3BAV2_LATCH | Uncharacterized protein. (105 aa) |
| | RFC5 | Replication factor C subunit 5. (333 aa) |
| | EXO1 | Exonuclease 1. (805 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (341 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2289 aa) |
| | RAD51B | RAD51 paralog B. (250 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (133 aa) |
| | H3BDB3_LATCH | Uncharacterized protein. (402 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (906 aa) |
| | RFC4 | Replication factor C subunit 4. (360 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (341 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (389 aa) |
| | RFC2 | Replication factor C subunit 2. (396 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (617 aa) |
| | ATRIP | ATR interacting protein. (782 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | TIMELESS | Timeless circadian regulator. (1272 aa) |
| | M3XGI0_LATCH | Uncharacterized protein. (117 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (411 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (319 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (866 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (609 aa) |
| | POLE3 | Polymerase (DNA directed), epsilon 3 (p17 subunit). (170 aa) |
| | LOC102365863 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | M3XK07_LATCH | Uncharacterized protein. (251 aa) |
| | M3XK14_LATCH | Uncharacterized protein. (196 aa) |
| | MEIOB | Meiosis specific with OB-fold. (470 aa) |
| | M3XL57_LATCH | Reverse transcriptase domain-containing protein. (332 aa) |
| | M3XL87_LATCH | Uncharacterized protein. (157 aa) |
