STRINGSTRING
CHEK2 CHEK2 H2ZS39_LATCH H2ZS39_LATCH H2ZS42_LATCH H2ZS42_LATCH H2ZVL4_LATCH H2ZVL4_LATCH UBE2V2 UBE2V2 EYA2 EYA2 H2ZZP4_LATCH H2ZZP4_LATCH RNF169 RNF169 LOC102346166 LOC102346166 LOC102350907 LOC102350907 H3A2S8_LATCH H3A2S8_LATCH H3A427_LATCH H3A427_LATCH LOC102361505 LOC102361505 EYA4 EYA4 H3A4B2_LATCH H3A4B2_LATCH MRE11 MRE11 H3A560_LATCH H3A560_LATCH APBB1 APBB1 H3A5E7_LATCH H3A5E7_LATCH H4C11 H4C11 ATM ATM ANKRD12 ANKRD12 EYA3 EYA3 H3A8A9_LATCH H3A8A9_LATCH BRCA1 BRCA1 H3ABB9_LATCH H3ABB9_LATCH RNF8 RNF8 H3ABS6_LATCH H3ABS6_LATCH H3AE13_LATCH H3AE13_LATCH H3AEU7_LATCH H3AEU7_LATCH UIMC1 UIMC1 UBE2N UBE2N H3AF58_LATCH H3AF58_LATCH H3AFK9_LATCH H3AFK9_LATCH RPS27A RPS27A LOC102347040 LOC102347040 KXD1 KXD1 NBN NBN H3AIY4_LATCH H3AIY4_LATCH TP53BP1 TP53BP1 H3AK44_LATCH H3AK44_LATCH H3AKN8_LATCH H3AKN8_LATCH H3ALL9_LATCH H3ALL9_LATCH BABAM1 BABAM1 ANKRD11 ANKRD11 H3APN8_LATCH H3APN8_LATCH H2BE1 H2BE1 NSD2 NSD2 PIAS4 PIAS4 ABRAXAS1 ABRAXAS1 PWWP2A PWWP2A H3AWE1_LATCH H3AWE1_LATCH APBB2 APBB2 H3AYY3_LATCH H3AYY3_LATCH KPNA7 KPNA7 H3B1Z1_LATCH H3B1Z1_LATCH TP53 TP53 LOC102350007 LOC102350007 KPNA2 KPNA2 BRCC3 BRCC3 EYA1 EYA1 H3BDB3_LATCH H3BDB3_LATCH UBXN1 UBXN1 BAP1 BAP1 M3XGI0_LATCH M3XGI0_LATCH BARD1 BARD1 LOC102365863 LOC102365863 M3XK07_LATCH M3XK07_LATCH M3XK14_LATCH M3XK14_LATCH M3XL57_LATCH M3XL57_LATCH M3XL87_LATCH M3XL87_LATCH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHEK2Checkpoint kinase 2. (411 aa)
H2ZS39_LATCHHistone H2B; Belongs to the histone H2B family. (135 aa)
H2ZS42_LATCHAAA_23 domain-containing protein. (88 aa)
H2ZVL4_LATCHHistone domain-containing protein; Belongs to the histone H2B family. (90 aa)
UBE2V2Ubiquitin conjugating enzyme E2 V2. (55 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (579 aa)
H2ZZP4_LATCHHistone H2B; Belongs to the histone H2B family. (138 aa)
RNF169Ring finger protein 169. (684 aa)
LOC102346166Ubiquitin-like domain-containing protein. (95 aa)
LOC102350907Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
H3A2S8_LATCHHistone H2B; Belongs to the histone H2B family. (138 aa)
H3A427_LATCHHistone H2B; Belongs to the histone H2B family. (137 aa)
LOC102361505Histone H2B; Belongs to the histone H2B family. (126 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (620 aa)
H3A4B2_LATCHReverse transcriptase domain-containing protein. (787 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (710 aa)
H3A560_LATCHRAD50 homolog, double strand break repair protein. (1193 aa)
APBB1Uncharacterized protein. (241 aa)
H3A5E7_LATCHHistone H2B; Belongs to the histone H2B family. (130 aa)
H4C11Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
ATMATM serine/threonine kinase. (2375 aa)
ANKRD12Ankyrin repeat domain 12. (2105 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (593 aa)
H3A8A9_LATCHUncharacterized protein. (271 aa)
BRCA1BRCA1 DNA repair associated. (1873 aa)
H3ABB9_LATCHWW domain-containing protein. (127 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (542 aa)
H3ABS6_LATCHUncharacterized protein. (443 aa)
H3AE13_LATCHUncharacterized protein. (380 aa)
H3AEU7_LATCHUncharacterized protein. (261 aa)
UIMC1Ubiquitin interaction motif containing 1. (735 aa)
UBE2NUbiquitin-conjugating enzyme E2Na; Belongs to the ubiquitin-conjugating enzyme family. (159 aa)
H3AF58_LATCHUncharacterized protein. (251 aa)
H3AFK9_LATCHRING-type domain-containing protein. (482 aa)
RPS27ARibosomal protein S27a. (156 aa)
LOC102347040Ubiquitin-conjugating enzyme E2Ia; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
KXD1Ubiquitin-like domain-containing protein. (231 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (772 aa)
H3AIY4_LATCHUncharacterized protein. (161 aa)
TP53BP1Tumor protein p53 binding protein 1. (2149 aa)
H3AK44_LATCHHistone domain-containing protein; Belongs to the histone H2B family. (105 aa)
H3AKN8_LATCHUncharacterized protein. (129 aa)
H3ALL9_LATCHUncharacterized protein. (251 aa)
BABAM1BRISC and BRCA1 A complex member 1. (323 aa)
ANKRD11Ankyrin repeat domain 11. (2717 aa)
H3APN8_LATCHReverse transcriptase domain-containing protein. (202 aa)
H2BE1Histone H2B; Belongs to the histone H2B family. (122 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1348 aa)
PIAS4Protein inhibitor of activated STAT 4. (370 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (412 aa)
PWWP2APWWP domain containing 2A. (843 aa)
H3AWE1_LATCHUncharacterized protein. (135 aa)
APBB2Amyloid beta precursor protein binding family B member 2. (745 aa)
H3AYY3_LATCHUncharacterized protein. (223 aa)
KPNA7Importin subunit alpha; Belongs to the importin alpha family. (521 aa)
H3B1Z1_LATCHUncharacterized protein. (352 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
LOC102350007Small ubiquitin-related modifier. (100 aa)
KPNA2Importin subunit alpha; Belongs to the importin alpha family. (517 aa)
BRCC3BRCA1/BRCA2-containing complex subunit 3. (291 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (646 aa)
H3BDB3_LATCHUncharacterized protein. (402 aa)
UBXN1UBX domain protein 1. (320 aa)
BAP1BRCA1 associated protein 1. (721 aa)
M3XGI0_LATCHUncharacterized protein. (117 aa)
BARD1BRCA1 associated RING domain 1. (866 aa)
LOC102365863UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
M3XK07_LATCHUncharacterized protein. (251 aa)
M3XK14_LATCHUncharacterized protein. (196 aa)
M3XL57_LATCHReverse transcriptase domain-containing protein. (332 aa)
M3XL87_LATCHUncharacterized protein. (157 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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