(5 nodes) Interleukin-10 signaling network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102356003	SH2 domain-containing protein. (170 aa)
	IL10	Interleukin 10. (185 aa)
	JAK1	Janus kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (613 aa)
	STAT3	Signal transducer and activator of transcription. (763 aa)
	IL18	Uncharacterized protein. (200 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL10	IL18	ENSLACP00000005382	ENSLACP00000021930	Interleukin 10.	Uncharacterized protein.	0.872
IL10	JAK1	ENSLACP00000005382	ENSLACP00000007727	Interleukin 10.	Janus kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.525
IL10	STAT3	ENSLACP00000005382	ENSLACP00000013656	Interleukin 10.	Signal transducer and activator of transcription.	0.821
IL18	IL10	ENSLACP00000021930	ENSLACP00000005382	Uncharacterized protein.	Interleukin 10.	0.872
IL18	STAT3	ENSLACP00000021930	ENSLACP00000013656	Uncharacterized protein.	Signal transducer and activator of transcription.	0.468
JAK1	IL10	ENSLACP00000007727	ENSLACP00000005382	Janus kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Interleukin 10.	0.525
JAK1	LOC102356003	ENSLACP00000007727	ENSLACP00000003584	Janus kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	SH2 domain-containing protein.	0.900
JAK1	STAT3	ENSLACP00000007727	ENSLACP00000013656	Janus kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Signal transducer and activator of transcription.	0.915
LOC102356003	JAK1	ENSLACP00000003584	ENSLACP00000007727	SH2 domain-containing protein.	Janus kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.900
LOC102356003	STAT3	ENSLACP00000003584	ENSLACP00000013656	SH2 domain-containing protein.	Signal transducer and activator of transcription.	0.808
STAT3	IL10	ENSLACP00000013656	ENSLACP00000005382	Signal transducer and activator of transcription.	Interleukin 10.	0.821
STAT3	IL18	ENSLACP00000013656	ENSLACP00000021930	Signal transducer and activator of transcription.	Uncharacterized protein.	0.468
STAT3	JAK1	ENSLACP00000013656	ENSLACP00000007727	Signal transducer and activator of transcription.	Janus kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.915
STAT3	LOC102356003	ENSLACP00000013656	ENSLACP00000003584	Signal transducer and activator of transcription.	SH2 domain-containing protein.	0.808