STRINGSTRING
ORC3 ORC3 KXD1 KXD1 LOC102367082 LOC102367082 PSMF1 PSMF1 H3AK44_LATCH H3AK44_LATCH RPA3 RPA3 LOC102361505 LOC102361505 H3A427_LATCH H3A427_LATCH H3A2S8_LATCH H3A2S8_LATCH LOC102350907 LOC102350907 FZR1 FZR1 LOC102365114 LOC102365114 CUL1 CUL1 LOC102346166 LOC102346166 RFC1 RFC1 PSME1 PSME1 GINS4 GINS4 H2ZZP4_LATCH H2ZZP4_LATCH PSMC2 PSMC2 PSME3 PSME3 CCNE1 CCNE1 CCNE2 CCNE2 PSMD6 PSMD6 PSME4 PSME4 MCM10 MCM10 FEN1 FEN1 H2ZVL4_LATCH H2ZVL4_LATCH PSMB6 PSMB6 CCNA2 CCNA2 PSME2 PSME2 PSMA4 PSMA4 CDT1 CDT1 ORC4 ORC4 LOC102351398 LOC102351398 PSMD1 PSMD1 CDC16 CDC16 PSMB1 PSMB1 H2ZS39_LATCH H2ZS39_LATCH PSMC4 PSMC4 H3AKZ0_LATCH H3AKZ0_LATCH H3AL79_LATCH H3AL79_LATCH POLD3 POLD3 FAM89B FAM89B MCM6 MCM6 H3ALV1_LATCH H3ALV1_LATCH CDC7 CDC7 RFC3 RFC3 PSMD11 PSMD11 H2BE1 H2BE1 PSMC5 PSMC5 RCBTB1 RCBTB1 H3AR57_LATCH H3AR57_LATCH PSMD7 PSMD7 POLD4 POLD4 MCM2 MCM2 KPNA6 KPNA6 KPNA5 KPNA5 H3ATF5_LATCH H3ATF5_LATCH ANAPC1 ANAPC1 PSMA8 PSMA8 ORC1 ORC1 SKP2 SKP2 H2AZ2 H2AZ2 PSMD12 PSMD12 MCM9 MCM9 TM7SF3 TM7SF3 PSMA1 PSMA1 PSMD10 PSMD10 DBF4 DBF4 PSMA2 PSMA2 POLD2 POLD2 DNA2 DNA2 ANAPC10 ANAPC10 ORC5 ORC5 MCM4 MCM4 PSMB10 PSMB10 ANAPC2 ANAPC2 PSMB8 PSMB8 PSMC1 PSMC1 PSMB9 PSMB9 ORC2 ORC2 PSMD5 PSMD5 H3B3C1_LATCH H3B3C1_LATCH KIAA2012 KIAA2012 PSMD3 PSMD3 PSMB11 PSMB11 LOC102358862 LOC102358862 CDC45 CDC45 LOC102350961 LOC102350961 POLD1 POLD1 CDC27 CDC27 PSMD8 PSMD8 PSMA5 PSMA5 POLE2 POLE2 ANAPC7 ANAPC7 PSMB2 PSMB2 MCM8 MCM8 CREBZF CREBZF SKP1 SKP1 ATAD5 ATAD5 RFC5 RFC5 POLE POLE CDC23 CDC23 POLE4 POLE4 ANAPC16 ANAPC16 KPNB1 KPNB1 PSMA6 PSMA6 RFC4 RFC4 LOC102365446 LOC102365446 PSMD9 PSMD9 ANAPC5 ANAPC5 RFC2 RFC2 UBE2C UBE2C PRIM1 PRIM1 PSMB7 PSMB7 PSMA3 PSMA3 PSMC3 PSMC3 CDK2 CDK2 PSMC6 PSMC6 LOC102349804 LOC102349804 BICRA BICRA PRIM2 PRIM2 CDC26 CDC26 POLE3 POLE3 MEIOB MEIOB LOC102362445 LOC102362445 GINS1 GINS1 RCBTB2 RCBTB2 PSMB4 PSMB4 H3A4V8_LATCH H3A4V8_LATCH PSMD14 PSMD14 GINS2 GINS2 H3A5E7_LATCH H3A5E7_LATCH H4C11 H4C11 MCM7 MCM7 PSMA7 PSMA7 PSMB3 PSMB3 ANAPC11 ANAPC11 RBX1 RBX1 KPNA1 KPNA1 ORC6 ORC6 MCM5 MCM5 GINS3 GINS3 PCNA PCNA PSMD13 PSMD13 UBE2S UBE2S RPA1 RPA1 CCNA1 CCNA1 RPS27A RPS27A MCM3 MCM3 LOC102367189 LOC102367189 GMNN GMNN PSMD2 PSMD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ORC3Origin recognition complex subunit 3. (720 aa)
KXD1Ubiquitin-like domain-containing protein. (231 aa)
LOC102367082XPGI domain-containing protein. (317 aa)
PSMF1Proteasome inhibitor subunit 1. (265 aa)
H3AK44_LATCHHistone domain-containing protein; Belongs to the histone H2B family. (105 aa)
RPA3Replication protein A3. (121 aa)
LOC102361505Histone H2B; Belongs to the histone H2B family. (126 aa)
H3A427_LATCHHistone H2B; Belongs to the histone H2B family. (137 aa)
H3A2S8_LATCHHistone H2B; Belongs to the histone H2B family. (138 aa)
LOC102350907Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
FZR1Fizzy and cell division cycle 20 related 1. (493 aa)
LOC102365114Uncharacterized protein. (496 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
LOC102346166Ubiquitin-like domain-containing protein. (95 aa)
RFC1Replication factor C subunit 1. (1152 aa)
PSME1Proteasome activator subunit 1. (252 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (190 aa)
H2ZZP4_LATCHHistone H2B; Belongs to the histone H2B family. (138 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (445 aa)
PSME3Proteasome activator subunit 3. (257 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (417 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (307 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
PSME4Proteasome activator subunit 4. (1848 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (878 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (317 aa)
H2ZVL4_LATCHHistone domain-containing protein; Belongs to the histone H2B family. (90 aa)
PSMB6Proteasome subunit beta. (245 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (447 aa)
PSME2Proteasome activator subunit 2. (241 aa)
PSMA4Proteasome subunit alpha type. (272 aa)
CDT1Chromatin licensing and DNA replication factor 1. (520 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (360 aa)
LOC102351398Uncharacterized protein. (117 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (730 aa)
CDC16Cell division cycle 16. (545 aa)
PSMB1Proteasome subunit beta. (203 aa)
H2ZS39_LATCHHistone H2B; Belongs to the histone H2B family. (135 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (316 aa)
H3AKZ0_LATCHPolymerase (DNA directed), alpha 1. (630 aa)
H3AL79_LATCHDNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
POLD3Uncharacterized protein. (373 aa)
FAM89BFamily with sequence similarity 89 member B. (179 aa)
MCM6DNA helicase; Belongs to the MCM family. (826 aa)
H3ALV1_LATCHUncharacterized protein. (375 aa)
CDC7Cell division cycle 7. (560 aa)
RFC3Replication factor C subunit 3. (237 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
H2BE1Histone H2B; Belongs to the histone H2B family. (122 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
H3AR57_LATCHDNA_pol_B domain-containing protein. (238 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
POLD4Uncharacterized protein. (122 aa)
MCM2DNA helicase; Belongs to the MCM family. (888 aa)
KPNA6Importin subunit alpha; Belongs to the importin alpha family. (540 aa)
KPNA5Importin subunit alpha; Belongs to the importin alpha family. (547 aa)
H3ATF5_LATCHCdc6_C domain-containing protein. (525 aa)
ANAPC1Anaphase promoting complex subunit 1. (1891 aa)
PSMA8Proteasome subunit alpha type. (251 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (894 aa)
SKP2S-phase kinase associated protein 2. (423 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (149 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (455 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1120 aa)
TM7SF3Transmembrane 7 superfamily member 3. (575 aa)
PSMA1Proteasome subunit alpha type. (269 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (234 aa)
DBF4DBF4 zinc finger. (672 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
DNA2DNA replication helicase/nuclease 2. (925 aa)
ANAPC10Anaphase promoting complex subunit 10. (147 aa)
ORC5Origin recognition complex subunit 5. (264 aa)
MCM4DNA helicase; Belongs to the MCM family. (858 aa)
PSMB10Proteasome subunit beta. (278 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (816 aa)
PSMB8Proteasome subunit beta. (271 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (451 aa)
PSMB9Proteasome subunit beta. (219 aa)
ORC2Origin recognition complex subunit 2. (568 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (501 aa)
H3B3C1_LATCHUncharacterized protein. (130 aa)
KIAA2012Uncharacterized protein. (695 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (524 aa)
PSMB11Proteasome subunit beta. (269 aa)
LOC102358862Proteasome subunit beta. (272 aa)
CDC45Cell division cycle 45. (609 aa)
LOC102350961Proteasome subunit beta. (260 aa)
POLD1DNA polymerase. (1103 aa)
CDC27Cell division cycle 27. (833 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (309 aa)
PSMA5Proteasome subunit alpha type. (244 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (531 aa)
ANAPC7Anaphase promoting complex subunit 7. (565 aa)
PSMB2Proteasome subunit beta. (199 aa)
MCM8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (852 aa)
CREBZFCREB/ATF bZIP transcription factor. (300 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (172 aa)
ATAD5ATPase family AAA domain containing 5. (1828 aa)
RFC5Replication factor C subunit 5. (333 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2289 aa)
CDC23Cell division cycle 23. (581 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (133 aa)
ANAPC16Anaphase promoting complex subunit 16. (119 aa)
KPNB1Karyopherin subunit beta 1. (777 aa)
PSMA6Proteasome subunit alpha type. (289 aa)
RFC4Replication factor C subunit 4. (360 aa)
LOC102365446Proteasome subunit alpha type. (246 aa)
PSMD9Proteasome 26S subunit, non-ATPase 9. (210 aa)
ANAPC5Anaphase promoting complex subunit 5. (755 aa)
RFC2Replication factor C subunit 2. (396 aa)
UBE2CUbiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa)
PSMB7Proteasome subunit beta 7. (289 aa)
PSMA3Proteasome subunit alpha type. (259 aa)
PSMC3Proteasome 26S subunit, ATPase 3. (192 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
LOC102349804Proteasome subunit alpha type. (274 aa)
BICRABRD4 interacting chromatin remodeling complex associated protein. (1753 aa)
PRIM2DNA primase subunit 2. (321 aa)
CDC26Cell division cycle 26. (85 aa)
POLE3Polymerase (DNA directed), epsilon 3 (p17 subunit). (170 aa)
MEIOBMeiosis specific with OB-fold. (470 aa)
LOC102362445PCI domain-containing protein. (376 aa)
GINS1GINS complex subunit 1. (196 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (413 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (274 aa)
H3A4V8_LATCHProteasome subunit beta. (260 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (314 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
H3A5E7_LATCHHistone H2B; Belongs to the histone H2B family. (130 aa)
H4C11Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (614 aa)
PSMA7Proteasome subunit alpha type. (251 aa)
PSMB3Proteasome subunit beta 3. (159 aa)
ANAPC11APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa)
RBX1Ring-box 1. (108 aa)
KPNA1Importin subunit alpha; Belongs to the importin alpha family. (538 aa)
ORC6Origin recognition complex subunit 6. (257 aa)
MCM5DNA helicase; Belongs to the MCM family. (635 aa)
GINS3GINS complex subunit 3. (156 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (378 aa)
UBE2SUbiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (181 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (495 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (433 aa)
RPS27ARibosomal protein S27a. (156 aa)
MCM3DNA helicase; Belongs to the MCM family. (820 aa)
LOC102367189Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (342 aa)
GMNNGeminin DNA replication inhibitor. (231 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (899 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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