(13 nodes) Depurination network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H4C11	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	H3AK44_LATCH	Histone domain-containing protein; Belongs to the histone H2B family. (105 aa)
	H2BE1	Histone H2B; Belongs to the histone H2B family. (122 aa)
	MPG	N-methylpurine DNA glycosylase. (272 aa)
	MUTYH	Uncharacterized protein. (140 aa)
	H2ZVL4_LATCH	Histone domain-containing protein; Belongs to the histone H2B family. (90 aa)
	H2ZS39_LATCH	Histone H2B; Belongs to the histone H2B family. (135 aa)
	H3A5E7_LATCH	Histone H2B; Belongs to the histone H2B family. (130 aa)
	LOC102361505	Histone H2B; Belongs to the histone H2B family. (126 aa)
	H3A427_LATCH	Histone H2B; Belongs to the histone H2B family. (137 aa)
	H3A2S8_LATCH	Histone H2B; Belongs to the histone H2B family. (138 aa)
	H2ZZP4_LATCH	Histone H2B; Belongs to the histone H2B family. (138 aa)
	NEIL3	Nei like DNA glycosylase 3. (383 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H2BE1	H4C11	ENSLACP00000011755	ENSLACP00000004892	Histone H2B; Belongs to the histone H2B family.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.927
H2ZS39_LATCH	H4C11	ENSLACP00000000210	ENSLACP00000004892	Histone H2B; Belongs to the histone H2B family.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.928
H2ZVL4_LATCH	H4C11	ENSLACP00000001435	ENSLACP00000004892	Histone domain-containing protein; Belongs to the histone H2B family.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.927
H2ZZP4_LATCH	H4C11	ENSLACP00000002865	ENSLACP00000004892	Histone H2B; Belongs to the histone H2B family.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.927
H3A2S8_LATCH	H4C11	ENSLACP00000003949	ENSLACP00000004892	Histone H2B; Belongs to the histone H2B family.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.923
H3A427_LATCH	H4C11	ENSLACP00000004398	ENSLACP00000004892	Histone H2B; Belongs to the histone H2B family.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.927
H3A5E7_LATCH	H4C11	ENSLACP00000004868	ENSLACP00000004892	Histone H2B; Belongs to the histone H2B family.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.933
H3AK44_LATCH	H4C11	ENSLACP00000010015	ENSLACP00000004892	Histone domain-containing protein; Belongs to the histone H2B family.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.845
H4C11	H2BE1	ENSLACP00000004892	ENSLACP00000011755	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Histone H2B; Belongs to the histone H2B family.	0.927
H4C11	H2ZS39_LATCH	ENSLACP00000004892	ENSLACP00000000210	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Histone H2B; Belongs to the histone H2B family.	0.928
H4C11	H2ZVL4_LATCH	ENSLACP00000004892	ENSLACP00000001435	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Histone domain-containing protein; Belongs to the histone H2B family.	0.927
H4C11	H2ZZP4_LATCH	ENSLACP00000004892	ENSLACP00000002865	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Histone H2B; Belongs to the histone H2B family.	0.927
H4C11	H3A2S8_LATCH	ENSLACP00000004892	ENSLACP00000003949	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Histone H2B; Belongs to the histone H2B family.	0.923
H4C11	H3A427_LATCH	ENSLACP00000004892	ENSLACP00000004398	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Histone H2B; Belongs to the histone H2B family.	0.927
H4C11	H3A5E7_LATCH	ENSLACP00000004892	ENSLACP00000004868	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Histone H2B; Belongs to the histone H2B family.	0.933
H4C11	H3AK44_LATCH	ENSLACP00000004892	ENSLACP00000010015	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Histone domain-containing protein; Belongs to the histone H2B family.	0.845
H4C11	LOC102361505	ENSLACP00000004892	ENSLACP00000004456	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Histone H2B; Belongs to the histone H2B family.	0.925
LOC102361505	H4C11	ENSLACP00000004456	ENSLACP00000004892	Histone H2B; Belongs to the histone H2B family.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.925
MPG	MUTYH	ENSLACP00000020281	ENSLACP00000023303	N-methylpurine DNA glycosylase.	Uncharacterized protein.	0.479
MPG	NEIL3	ENSLACP00000020281	ENSLACP00000000340	N-methylpurine DNA glycosylase.	Nei like DNA glycosylase 3.	0.485