STRINGSTRING
TLR9 TLR9 FGFR4 FGFR4 FGF1 FGF1 PIK3CB PIK3CB FGF20 FGF20 FGF19 FGF19 FGF4 FGF4 FGF3 FGF3 LOC102351332 LOC102351332 FGF13 FGF13 FGFR1 FGFR1 PDPK1 PDPK1 FGF18 FGF18 FGF7 FGF7 FGF22 FGF22 PIK3R4 PIK3R4 FGF16 FGF16 GAB1 GAB1 FGF8 FGF8 FGF5 FGF5 PIK3CA PIK3CA PIK3C3 PIK3C3 FGF2 FGF2 FGF23 FGF23 FGF6 FGF6 LOC102352712 LOC102352712 FGFR3 FGFR3 GRB2 GRB2 SOS1 SOS1 GAB2 GAB2 LOC102356182 LOC102356182 TRIB3 TRIB3 FRS2 FRS2 PTPN11 PTPN11 H3ACE0_LATCH H3ACE0_LATCH FGFR2 FGFR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TLR9Toll-like receptor 9. (1039 aa)
FGFR4Fibroblast growth factor receptor. (810 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1077 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (237 aa)
LOC102351332Zgc:158659; Belongs to the PI3/PI4-kinase family. (1067 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
FGFR1Fibroblast growth factor receptor. (824 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (563 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (99 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1363 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
GAB1GRB2 associated binding protein 1. (534 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (825 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (249 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
LOC102352712Protein tyrosine phosphatase non-receptor type 11b. (553 aa)
FGFR3Fibroblast growth factor receptor. (778 aa)
GRB2Growth factor receptor bound protein 2. (292 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1331 aa)
GAB2GRB2 associated binding protein 2. (550 aa)
LOC102356182Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
TRIB3Tribbles pseudokinase 3. (353 aa)
FRS2Fibroblast growth factor receptor substrate 2. (502 aa)
PTPN11Protein tyrosine phosphatase non-receptor type 11. (586 aa)
H3ACE0_LATCHInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (111 aa)
FGFR2Fibroblast growth factor receptor. (810 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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