(40 nodes) Platelet Aggregation (Plug Formation) network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (618 aa)
	LOC102365269	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1331 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (439 aa)
	ADRA2C	Adrenoceptor alpha 2C. (434 aa)
	FGG	Fibrinogen gamma chain. (376 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (563 aa)
	LOC102350558	MFS domain-containing protein. (498 aa)
	GP1BB	Glycoprotein Ib platelet subunit beta. (204 aa)
	RAPGEF4	Rap guanine nucleotide exchange factor 4. (750 aa)
	LOC102361473	Uncharacterized protein. (1211 aa)
	NEDD9	Neural precursor cell expressed, developmentally down-regulated 9. (901 aa)
	H2ZZQ4_LATCH	LRRCT domain-containing protein. (200 aa)
	BCAR1	BCAR1 scaffold protein, Cas family member. (914 aa)
	FGA	Fibrinogen alpha chain. (723 aa)
	FGB	Fibrinogen beta chain. (454 aa)
	H3AHE4_LATCH	Uncharacterized protein. (463 aa)
	ADRA2B	Adrenoceptor alpha 2B. (452 aa)
	H3AM01_LATCH	Integrin beta; Belongs to the integrin beta chain family. (769 aa)
	RAPGEF5	Rap guanine nucleotide exchange factor 5. (368 aa)
	TLN1	Talin 1. (2546 aa)
	RASGRP1	RAS guanyl releasing protein 1. (719 aa)
	CRK	CRK proto-oncogene, adaptor protein. (310 aa)
	RAP1B	RAP1B, member of RAS oncogene family. (184 aa)
	SYK	Tyrosine-protein kinase. (616 aa)
	RAPH1	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1. (1312 aa)
	TLNRD1	Talin rod domain containing 1. (358 aa)
	TLN2	Talin 2. (1962 aa)
	RAPGEFL1	Rap guanine nucleotide exchange factor like 1. (421 aa)
	FNDC3B	Fibronectin type III domain containing 3B. (944 aa)
	LOC102353191	Si:ch211-237i5.4. (346 aa)
	MFSD8	Major facilitator superfamily domain containing 8. (522 aa)
	CASS4	Cas scaffold protein family member 4. (817 aa)
	RASGRP4	RAS guanyl releasing protein 4. (692 aa)
	LOC102351219	Rap guanine nucleotide exchange factor (GEF) 3. (376 aa)
	GRB2	Growth factor receptor bound protein 2. (292 aa)
	H2ZVQ3_LATCH	Uncharacterized protein. (603 aa)
	FNDC3A	Fibronectin type III domain containing 3A. (1198 aa)
	RAPGEF3	Ras-GEF domain-containing protein. (459 aa)
	RAP1A	RAP1A, member of RAS oncogene family b. (185 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRA2B	ADRA2C	ENSLACP00000009106	ENSLACP00000006102	Adrenoceptor alpha 2B.	Adrenoceptor alpha 2C.	0.481
ADRA2C	ADRA2B	ENSLACP00000006102	ENSLACP00000009106	Adrenoceptor alpha 2C.	Adrenoceptor alpha 2B.	0.481
ADRA2C	LOC102365269	ENSLACP00000006102	ENSLACP00000004246	Adrenoceptor alpha 2C.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.474
BCAR1	CRK	ENSLACP00000003747	ENSLACP00000011971	BCAR1 scaffold protein, Cas family member.	CRK proto-oncogene, adaptor protein.	0.983
BCAR1	FGA	ENSLACP00000003747	ENSLACP00000007992	BCAR1 scaffold protein, Cas family member.	Fibrinogen alpha chain.	0.498
BCAR1	GRB2	ENSLACP00000003747	ENSLACP00000000662	BCAR1 scaffold protein, Cas family member.	Growth factor receptor bound protein 2.	0.770
BCAR1	H3AM01_LATCH	ENSLACP00000003747	ENSLACP00000010672	BCAR1 scaffold protein, Cas family member.	Integrin beta; Belongs to the integrin beta chain family.	0.615
BCAR1	NEDD9	ENSLACP00000003747	ENSLACP00000002322	BCAR1 scaffold protein, Cas family member.	Neural precursor cell expressed, developmentally down-regulated 9.	0.502
BCAR1	PTPN1	ENSLACP00000003747	ENSLACP00000004428	BCAR1 scaffold protein, Cas family member.	Tyrosine-protein phosphatase non-receptor type.	0.662
BCAR1	RAP1A	ENSLACP00000003747	ENSLACP00000021077	BCAR1 scaffold protein, Cas family member.	RAP1A, member of RAS oncogene family b.	0.511
BCAR1	RAP1B	ENSLACP00000003747	ENSLACP00000012966	BCAR1 scaffold protein, Cas family member.	RAP1B, member of RAS oncogene family.	0.511
BCAR1	RAPH1	ENSLACP00000003747	ENSLACP00000013100	BCAR1 scaffold protein, Cas family member.	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1.	0.579
BCAR1	TLN1	ENSLACP00000003747	ENSLACP00000011342	BCAR1 scaffold protein, Cas family member.	Talin 1.	0.602
BCAR1	TLN2	ENSLACP00000003747	ENSLACP00000015702	BCAR1 scaffold protein, Cas family member.	Talin 2.	0.602
BCAR1	TLNRD1	ENSLACP00000003747	ENSLACP00000015118	BCAR1 scaffold protein, Cas family member.	Talin rod domain containing 1.	0.602
CASS4	CRK	ENSLACP00000018684	ENSLACP00000011971	Cas scaffold protein family member 4.	CRK proto-oncogene, adaptor protein.	0.656
CASS4	FGA	ENSLACP00000018684	ENSLACP00000007992	Cas scaffold protein family member 4.	Fibrinogen alpha chain.	0.470
CASS4	GRB2	ENSLACP00000018684	ENSLACP00000000662	Cas scaffold protein family member 4.	Growth factor receptor bound protein 2.	0.428
CASS4	RAP1A	ENSLACP00000018684	ENSLACP00000021077	Cas scaffold protein family member 4.	RAP1A, member of RAS oncogene family b.	0.492
CASS4	RAP1B	ENSLACP00000018684	ENSLACP00000012966	Cas scaffold protein family member 4.	RAP1B, member of RAS oncogene family.	0.492