(11 nodes) MET activates RAS signaling network (Latimeria chalumnae)

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Your Input:
	MET	MET proto-oncogene, receptor tyrosine kinase. (1385 aa)
	RANBP10	RAN binding protein 10. (606 aa)
	HRAS	HRas proto-oncogene, GTPase. (193 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	CSDE1	Cold shock domain containing E1. (854 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (720 aa)
	GRB2	Growth factor receptor bound protein 2. (292 aa)
	RANBP9	RAN binding protein 9. (650 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1331 aa)
	H3ARU2_LATCH	Uncharacterized protein. (152 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	GRB2	ENSLACP00000021001	ENSLACP00000000662	Cold shock domain containing E1.	Growth factor receptor bound protein 2.	0.667
CSDE1	HGF	ENSLACP00000021001	ENSLACP00000023353	Cold shock domain containing E1.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.413
CSDE1	MET	ENSLACP00000021001	ENSLACP00000015263	Cold shock domain containing E1.	MET proto-oncogene, receptor tyrosine kinase.	0.649
CSDE1	SOS1	ENSLACP00000021001	ENSLACP00000004382	Cold shock domain containing E1.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.714
GRB2	CSDE1	ENSLACP00000000662	ENSLACP00000021001	Growth factor receptor bound protein 2.	Cold shock domain containing E1.	0.667
GRB2	H3ARU2_LATCH	ENSLACP00000000662	ENSLACP00000012363	Growth factor receptor bound protein 2.	Uncharacterized protein.	0.667
GRB2	HGF	ENSLACP00000000662	ENSLACP00000023353	Growth factor receptor bound protein 2.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.678
GRB2	HRAS	ENSLACP00000000662	ENSLACP00000020973	Growth factor receptor bound protein 2.	HRas proto-oncogene, GTPase.	0.667
GRB2	KRAS	ENSLACP00000000662	ENSLACP00000022976	Growth factor receptor bound protein 2.	KRAS proto-oncogene, GTPase.	0.667
GRB2	MET	ENSLACP00000000662	ENSLACP00000015263	Growth factor receptor bound protein 2.	MET proto-oncogene, receptor tyrosine kinase.	0.963
GRB2	NRAS	ENSLACP00000000662	ENSLACP00000020975	Growth factor receptor bound protein 2.	NRAS proto-oncogene, GTPase.	0.667
GRB2	SOS1	ENSLACP00000000662	ENSLACP00000004382	Growth factor receptor bound protein 2.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.999
H3ARU2_LATCH	GRB2	ENSLACP00000012363	ENSLACP00000000662	Uncharacterized protein.	Growth factor receptor bound protein 2.	0.667
H3ARU2_LATCH	HGF	ENSLACP00000012363	ENSLACP00000023353	Uncharacterized protein.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.413
H3ARU2_LATCH	KRAS	ENSLACP00000012363	ENSLACP00000022976	Uncharacterized protein.	KRAS proto-oncogene, GTPase.	0.901
H3ARU2_LATCH	MET	ENSLACP00000012363	ENSLACP00000015263	Uncharacterized protein.	MET proto-oncogene, receptor tyrosine kinase.	0.649
H3ARU2_LATCH	SOS1	ENSLACP00000012363	ENSLACP00000004382	Uncharacterized protein.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.970
HGF	CSDE1	ENSLACP00000023353	ENSLACP00000021001	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Cold shock domain containing E1.	0.413
HGF	GRB2	ENSLACP00000023353	ENSLACP00000000662	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Growth factor receptor bound protein 2.	0.678
HGF	H3ARU2_LATCH	ENSLACP00000023353	ENSLACP00000012363	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Uncharacterized protein.	0.413