(6 nodes) MET activates PI3K/AKT signaling network (Latimeria chalumnae)

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Your Input:
	GRB2	Growth factor receptor bound protein 2. (292 aa)
	GAB1	GRB2 associated binding protein 1. (534 aa)
	LOC102351332	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1067 aa)
	MET	MET proto-oncogene, receptor tyrosine kinase. (1385 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (720 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GAB1	GRB2	ENSLACP00000009784	ENSLACP00000000662	GRB2 associated binding protein 1.	Growth factor receptor bound protein 2.	0.999
GAB1	HGF	ENSLACP00000009784	ENSLACP00000023353	GRB2 associated binding protein 1.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.768
GAB1	LOC102351332	ENSLACP00000009784	ENSLACP00000013502	GRB2 associated binding protein 1.	Zgc:158659; Belongs to the PI3/PI4-kinase family.	0.548
GAB1	MET	ENSLACP00000009784	ENSLACP00000015263	GRB2 associated binding protein 1.	MET proto-oncogene, receptor tyrosine kinase.	0.996
GAB1	PIK3CA	ENSLACP00000009784	ENSLACP00000017606	GRB2 associated binding protein 1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.952
GRB2	GAB1	ENSLACP00000000662	ENSLACP00000009784	Growth factor receptor bound protein 2.	GRB2 associated binding protein 1.	0.999
GRB2	HGF	ENSLACP00000000662	ENSLACP00000023353	Growth factor receptor bound protein 2.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.678
GRB2	LOC102351332	ENSLACP00000000662	ENSLACP00000013502	Growth factor receptor bound protein 2.	Zgc:158659; Belongs to the PI3/PI4-kinase family.	0.657
GRB2	MET	ENSLACP00000000662	ENSLACP00000015263	Growth factor receptor bound protein 2.	MET proto-oncogene, receptor tyrosine kinase.	0.963
GRB2	PIK3CA	ENSLACP00000000662	ENSLACP00000017606	Growth factor receptor bound protein 2.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.764
HGF	GAB1	ENSLACP00000023353	ENSLACP00000009784	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	GRB2 associated binding protein 1.	0.768
HGF	GRB2	ENSLACP00000023353	ENSLACP00000000662	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Growth factor receptor bound protein 2.	0.678
HGF	LOC102351332	ENSLACP00000023353	ENSLACP00000013502	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Zgc:158659; Belongs to the PI3/PI4-kinase family.	0.496
HGF	MET	ENSLACP00000023353	ENSLACP00000015263	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	MET proto-oncogene, receptor tyrosine kinase.	0.998
HGF	PIK3CA	ENSLACP00000023353	ENSLACP00000017606	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.572
LOC102351332	GAB1	ENSLACP00000013502	ENSLACP00000009784	Zgc:158659; Belongs to the PI3/PI4-kinase family.	GRB2 associated binding protein 1.	0.548
LOC102351332	GRB2	ENSLACP00000013502	ENSLACP00000000662	Zgc:158659; Belongs to the PI3/PI4-kinase family.	Growth factor receptor bound protein 2.	0.657
LOC102351332	HGF	ENSLACP00000013502	ENSLACP00000023353	Zgc:158659; Belongs to the PI3/PI4-kinase family.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.496
LOC102351332	MET	ENSLACP00000013502	ENSLACP00000015263	Zgc:158659; Belongs to the PI3/PI4-kinase family.	MET proto-oncogene, receptor tyrosine kinase.	0.699
MET	GAB1	ENSLACP00000015263	ENSLACP00000009784	MET proto-oncogene, receptor tyrosine kinase.	GRB2 associated binding protein 1.	0.996