(13 nodes) VLDLR internalisation and degradation network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CLHC1	Clathrin heavy chain linker domain-containing protein 1. (510 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (375 aa)
	LOC102357859	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (992 aa)
	LOC102346166	Ubiquitin-like domain-containing protein. (95 aa)
	LOC102350907	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	RPS27A	Ribosomal protein S27a. (156 aa)
	KXD1	Ubiquitin-like domain-containing protein. (231 aa)
	MYLIP	Myosin regulatory light chain interacting protein. (443 aa)
	PCSK9	Proprotein convertase subtilisin/kexin type 9. (672 aa)
	AP2S1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
	AP2A1	Alpha_adaptinC2 domain-containing protein. (737 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (426 aa)
	AP2M1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (434 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP2A1	AP2M1	ENSLACP00000019999	ENSLACP00000015716	Alpha_adaptinC2 domain-containing protein.	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.999
AP2A1	AP2S1	ENSLACP00000019999	ENSLACP00000014068	Alpha_adaptinC2 domain-containing protein.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.999
AP2A1	CLHC1	ENSLACP00000019999	ENSLACP00000022627	Alpha_adaptinC2 domain-containing protein.	Clathrin heavy chain linker domain-containing protein 1.	0.832
AP2A1	LOC102346166	ENSLACP00000019999	ENSLACP00000003410	Alpha_adaptinC2 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.605
AP2A1	LOC102357859	ENSLACP00000019999	ENSLACP00000001698	Alpha_adaptinC2 domain-containing protein.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.660
AP2A1	RPS27A	ENSLACP00000019999	ENSLACP00000008678	Alpha_adaptinC2 domain-containing protein.	Ribosomal protein S27a.	0.670
AP2M1	AP2A1	ENSLACP00000015716	ENSLACP00000019999	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Alpha_adaptinC2 domain-containing protein.	0.999
AP2M1	AP2S1	ENSLACP00000015716	ENSLACP00000014068	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.999
AP2M1	CLHC1	ENSLACP00000015716	ENSLACP00000022627	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Clathrin heavy chain linker domain-containing protein 1.	0.794
AP2M1	KXD1	ENSLACP00000015716	ENSLACP00000009213	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Ubiquitin-like domain-containing protein.	0.641
AP2M1	LOC102346166	ENSLACP00000015716	ENSLACP00000003410	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Ubiquitin-like domain-containing protein.	0.646
AP2M1	LOC102350907	ENSLACP00000015716	ENSLACP00000003879	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.641
AP2M1	LOC102357859	ENSLACP00000015716	ENSLACP00000001698	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.998
AP2M1	RPS27A	ENSLACP00000015716	ENSLACP00000008678	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Ribosomal protein S27a.	0.708
AP2S1	AP2A1	ENSLACP00000014068	ENSLACP00000019999	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Alpha_adaptinC2 domain-containing protein.	0.999
AP2S1	AP2M1	ENSLACP00000014068	ENSLACP00000015716	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.999
AP2S1	CLHC1	ENSLACP00000014068	ENSLACP00000022627	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Clathrin heavy chain linker domain-containing protein 1.	0.771
AP2S1	KXD1	ENSLACP00000014068	ENSLACP00000009213	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Ubiquitin-like domain-containing protein.	0.618
AP2S1	LOC102346166	ENSLACP00000014068	ENSLACP00000003410	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Ubiquitin-like domain-containing protein.	0.611
AP2S1	LOC102350907	ENSLACP00000014068	ENSLACP00000003879	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.618