(77 nodes) RHOG GTPase cycle network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MCF2	MCF.2 cell line derived transforming sequence b. (325 aa)
	TRIO	Trio Rho guanine nucleotide exchange factor. (3035 aa)
	DOCK4	Dedicator of cytokinesis 4; Belongs to the DOCK family. (1826 aa)
	VAMP3	Vesicle associated membrane protein 3. (138 aa)
	EPHA2	Uncharacterized protein. (979 aa)
	MPP3	Membrane palmitoylated protein 3; Belongs to the MAGUK family. (586 aa)
	LOC102362077	Ras homolog gene family, member Gc. (192 aa)
	LOC102366450	Uncharacterized protein. (213 aa)
	H3AWC2_LATCH	Uncharacterized protein. (1538 aa)
	LOC102355766	Uncharacterized protein. (524 aa)
	H3AXK0_LATCH	Uncharacterized protein. (161 aa)
	LOC102359313	Uncharacterized protein. (334 aa)
	LBR	Lamin B receptor. (631 aa)
	BCAM	Uncharacterized protein. (665 aa)
	ARHGEF16	Rho guanine nucleotide exchange factor 16. (704 aa)
	M3XLD7_LATCH	Uncharacterized protein. (1155 aa)
	ARHGAP39	Rho GTPase activating protein 39. (1077 aa)
	M3XJQ7_LATCH	CBM20 domain-containing protein. (180 aa)
	DEPDC1B	DEP domain containing 1B. (529 aa)
	NDUFA5	Uncharacterized protein. (82 aa)
	KTN1	Kinectin 1. (1362 aa)
	NDUFS3	NADH:ubiquinone oxidoreductase core subunit S3. (255 aa)
	VAV2	Vav guanine nucleotide exchange factor 2. (519 aa)
	MAP3K10	Mitogen-activated protein kinase kinase kinase. (998 aa)
	RBM39	RNA binding motif protein 39. (531 aa)
	ARHGAP1	Rho GTPase activating protein 1. (318 aa)
	LOC102350663	Si:ch211-218g4.2. (1040 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
	LOC102354637	Core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1a. (386 aa)
	MCF2L2	MCF.2 cell line derived transforming sequence-like 2. (995 aa)
	ANKLE2	Ankyrin repeat and LEM domain containing 2. (956 aa)
	DOCK2	Dedicator of cytokinesis 2; Belongs to the DOCK family. (1830 aa)
	ARHGAP32	Rho GTPase activating protein 32. (1934 aa)
	DOCK3	Dedicator of cytokinesis 3; Belongs to the DOCK family. (1648 aa)
	DOCK5	Dedicator of cytokinesis 5; Belongs to the DOCK family. (1866 aa)
	LOC102354318	Uncharacterized protein. (516 aa)
	MCAM	Melanoma cell adhesion molecule. (634 aa)
	CDC42	Cell division cycle 42. (156 aa)
	CYFIP1	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1259 aa)
	RAB7A	RAB7A, member RAS oncogene family. (207 aa)
	ARHGEF26	Rho guanine nucleotide exchange factor 26. (899 aa)
	HSPE1	Heat shock protein family E (Hsp10) member 1; Belongs to the GroES chaperonin family. (114 aa)
	PGRMC2	Progesterone receptor membrane component 2; Belongs to the cytochrome b5 family. (193 aa)
	H3B3H9_LATCH	Uncharacterized protein. (1311 aa)
	YKT6	YKT6 v-SNARE homolog; Belongs to the synaptobrevin family. (199 aa)
	DOCK1	Dedicator of cytokinesis 1; Belongs to the DOCK family. (873 aa)
	LETM2	Leucine zipper and EF-hand containing transmembrane protein 2. (487 aa)
	RHOG	Ras homolog family member G. (191 aa)
	PLEKHG3	Pleckstrin homology and RhoGEF domain containing G3. (1077 aa)
	VAV3	Si:ch73-383g2.1. (488 aa)
	ARHGAP5	Rho GTPase activating protein 5. (1303 aa)
	KIAA0355	KIAA0355. (1082 aa)
	STX5	Syntaxin 5; Belongs to the syntaxin family. (350 aa)
	MCF2L	MCF.2 cell line derived transforming sequence like. (1140 aa)
	ARHGDIB	Rho GDP dissociation inhibitor beta. (149 aa)
	PAK2	Non-specific serine/threonine protein kinase. (521 aa)
	ARHGAP21	Rho GTPase activating protein 21. (1978 aa)
	H3A7S0_LATCH	Mitogen-activated protein kinase kinase kinase 21; Belongs to the protein kinase superfamily. (391 aa)
	ARHGDIA	Rho GDP dissociation inhibitor alpha. (204 aa)
	CDC42EP1	CDC42 effector protein (Rho GTPase binding) 1b. (210 aa)
	MPP7	Membrane palmitoylated protein 7; Belongs to the MAGUK family. (576 aa)
	H3AEM8_LATCH	DHR-1 domain-containing protein; Belongs to the DOCK family. (1002 aa)
	ARHGDIG	Uncharacterized protein. (197 aa)
	LETM1	Leucine zipper and EF-hand containing transmembrane protein 1. (558 aa)
	VRK2	VRK serine/threonine kinase 2. (482 aa)
	LMAN1	Lectin, mannose binding 1. (332 aa)
	MAP3K9	Mitogen-activated protein kinase kinase kinase. (900 aa)
	VAPB	VAMP associated protein B and C. (242 aa)
	H3AJ45_LATCH	Uncharacterized protein. (651 aa)
	LOC102352152	Uncharacterized protein. (206 aa)
	H3AL82_LATCH	Uncharacterized protein. (245 aa)
	MAP3K11	Mitogen-activated protein kinase kinase kinase 11. (831 aa)
	FPGT	TNNI3 interacting kinase. (938 aa)
	H3ANT7_LATCH	Uncharacterized protein; Belongs to the DOCK family. (790 aa)
	ITSN1	Intersectin 1 (SH3 domain protein). (1175 aa)
	LEMD3	LEM domain containing 3. (705 aa)
	ARHGAP35	Rho GTPase activating protein 35b. (1487 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKLE2	LEMD3	ENSLACP00000020221	ENSLACP00000011530	Ankyrin repeat and LEM domain containing 2.	LEM domain containing 3.	0.452
ANKLE2	LOC102354318	ENSLACP00000020221	ENSLACP00000018831	Ankyrin repeat and LEM domain containing 2.	Uncharacterized protein.	0.462
ANKLE2	LOC102362077	ENSLACP00000020221	ENSLACP00000013451	Ankyrin repeat and LEM domain containing 2.	Ras homolog gene family, member Gc.	0.585
ANKLE2	RBM39	ENSLACP00000020221	ENSLACP00000021409	Ankyrin repeat and LEM domain containing 2.	RNA binding motif protein 39.	0.462
ANKLE2	RHOG	ENSLACP00000020221	ENSLACP00000014649	Ankyrin repeat and LEM domain containing 2.	Ras homolog family member G.	0.585
ANKLE2	VRK2	ENSLACP00000020221	ENSLACP00000009123	Ankyrin repeat and LEM domain containing 2.	VRK serine/threonine kinase 2.	0.842
ARHGAP1	ARHGAP39	ENSLACP00000021395	ENSLACP00000023474	Rho GTPase activating protein 1.	Rho GTPase activating protein 39.	0.523
ARHGAP1	CDC42	ENSLACP00000021395	ENSLACP00000018010	Rho GTPase activating protein 1.	Cell division cycle 42.	0.986
ARHGAP1	DEPDC1B	ENSLACP00000021395	ENSLACP00000022308	Rho GTPase activating protein 1.	DEP domain containing 1B.	0.444
ARHGAP1	H3AJ45_LATCH	ENSLACP00000021395	ENSLACP00000009666	Rho GTPase activating protein 1.	Uncharacterized protein.	0.446
ARHGAP1	ITSN1	ENSLACP00000021395	ENSLACP00000011416	Rho GTPase activating protein 1.	Intersectin 1 (SH3 domain protein).	0.446
ARHGAP1	LOC102350663	ENSLACP00000021395	ENSLACP00000021380	Rho GTPase activating protein 1.	Si:ch211-218g4.2.	0.523
ARHGAP1	LOC102362077	ENSLACP00000021395	ENSLACP00000013451	Rho GTPase activating protein 1.	Ras homolog gene family, member Gc.	0.665
ARHGAP1	MPP3	ENSLACP00000021395	ENSLACP00000013428	Rho GTPase activating protein 1.	Membrane palmitoylated protein 3; Belongs to the MAGUK family.	0.508
ARHGAP1	MPP7	ENSLACP00000021395	ENSLACP00000007151	Rho GTPase activating protein 1.	Membrane palmitoylated protein 7; Belongs to the MAGUK family.	0.508
ARHGAP1	PAK2	ENSLACP00000021395	ENSLACP00000004711	Rho GTPase activating protein 1.	Non-specific serine/threonine protein kinase.	0.539
ARHGAP1	RHOG	ENSLACP00000021395	ENSLACP00000014649	Rho GTPase activating protein 1.	Ras homolog family member G.	0.665
ARHGAP21	CDC42	ENSLACP00000005209	ENSLACP00000018010	Rho GTPase activating protein 21.	Cell division cycle 42.	0.692
ARHGAP21	LOC102362077	ENSLACP00000005209	ENSLACP00000013451	Rho GTPase activating protein 21.	Ras homolog gene family, member Gc.	0.521
ARHGAP21	RHOG	ENSLACP00000005209	ENSLACP00000014649	Rho GTPase activating protein 21.	Ras homolog family member G.	0.521