Co-purification, co-crystallization, Yeast2Hybrid, Genetic Interactions, etc ... as imported from primary sources.
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Fusion
Genes that are sometimes fused into single open reading frames.
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Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TKT
Transketolase. (626 aa)
PDHB
Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (393 aa)
TKTL2
Transketolase like 2. (485 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897 Other names: L. chalumnae, coelacanth
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
node1
node2
node1 accession
node2 accession
node1 annotation
node2 annotation
score
PDHB
TKT
ENSLACP00000013979
ENSLACP00000022303
Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
Transketolase.
0.905
PDHB
TKTL2
ENSLACP00000013979
ENSLACP00000014856
Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
Transketolase like 2.
0.905
TKT
PDHB
ENSLACP00000022303
ENSLACP00000013979
Transketolase.
Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
0.905
TKT
TKTL2
ENSLACP00000022303
ENSLACP00000014856
Transketolase.
Transketolase like 2.
0.901
TKTL2
PDHB
ENSLACP00000014856
ENSLACP00000013979
Transketolase like 2.
Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
0.905
TKTL2
TKT
ENSLACP00000014856
ENSLACP00000022303
Transketolase like 2.
Transketolase.
0.901
[ The below analysis is limited to the network nodes included in the specified statistical background ]
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