(29 nodes) PMP-22/EMP/MP20/Claudin tight junction network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	EMP2	Epithelial membrane protein 2. (160 aa)
	LOC102352148	Lens intrinsic membrane protein 2.2. (172 aa)
	LIM2	Lens intrinsic membrane protein 2. (207 aa)
	TMEM182	Transmembrane protein 182. (242 aa)
	LOC102352776	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (233 aa)
	LOC102353037	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (233 aa)
	LOC102346705	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (213 aa)
	LOC102362746	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa)
	CACNG3	Calcium voltage-gated channel auxiliary subunit gamma 3. (246 aa)
	CLDN5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (213 aa)
	CLDN1	Claudin 1. (210 aa)
	PMP22	Peripheral myelin protein 22. (159 aa)
	CLDN19	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
	LOC102362450	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (192 aa)
	LOC102347840	Si:ch211-150g13.3. (292 aa)
	CLDN34	Uncharacterized protein. (257 aa)
	EMP3	Epithelial membrane protein 3. (161 aa)
	TMEM178B	Uncharacterized protein. (140 aa)
	LOC102365642	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (213 aa)
	LOC102352912	Uncharacterized protein. (209 aa)
	CACNG6	Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (253 aa)
	H3A812_LATCH	Uncharacterized protein. (193 aa)
	CLDN15	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (235 aa)
	CACNG8	Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (367 aa)
	CACNG7	Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (302 aa)
	LOC102358613	Uncharacterized protein. (249 aa)
	CLDN7	Claudin 7b. (145 aa)
	CACNG5	Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
	CACNG4	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (329 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLDN1	CLDN19	ENSLACP00000017569	ENSLACP00000020552	Claudin 1.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.671
CLDN1	CLDN34	ENSLACP00000017569	ENSLACP00000022250	Claudin 1.	Uncharacterized protein.	0.650
CLDN1	CLDN5	ENSLACP00000017569	ENSLACP00000017353	Claudin 1.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.784
CLDN1	CLDN7	ENSLACP00000017569	ENSLACP00000009714	Claudin 1.	Claudin 7b.	0.663
CLDN1	H3A812_LATCH	ENSLACP00000017569	ENSLACP00000005783	Claudin 1.	Uncharacterized protein.	0.748
CLDN1	LOC102346705	ENSLACP00000017569	ENSLACP00000013916	Claudin 1.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.698
CLDN1	LOC102352776	ENSLACP00000017569	ENSLACP00000012735	Claudin 1.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.694
CLDN1	LOC102352912	ENSLACP00000017569	ENSLACP00000005522	Claudin 1.	Uncharacterized protein.	0.676
CLDN1	LOC102353037	ENSLACP00000017569	ENSLACP00000012904	Claudin 1.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.694
CLDN1	LOC102362450	ENSLACP00000017569	ENSLACP00000020610	Claudin 1.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.746
CLDN1	LOC102362746	ENSLACP00000017569	ENSLACP00000014215	Claudin 1.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.761
CLDN1	LOC102365642	ENSLACP00000017569	ENSLACP00000005344	Claudin 1.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.736
CLDN15	CLDN34	ENSLACP00000006001	ENSLACP00000022250	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.668
CLDN19	CLDN1	ENSLACP00000020552	ENSLACP00000017569	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin 1.	0.671
CLDN19	CLDN34	ENSLACP00000020552	ENSLACP00000022250	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.650
CLDN19	CLDN5	ENSLACP00000020552	ENSLACP00000017353	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.704
CLDN19	CLDN7	ENSLACP00000020552	ENSLACP00000009714	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin 7b.	0.657
CLDN19	H3A812_LATCH	ENSLACP00000020552	ENSLACP00000005783	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.707
CLDN19	LOC102346705	ENSLACP00000020552	ENSLACP00000013916	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.694
CLDN19	LOC102352776	ENSLACP00000020552	ENSLACP00000012735	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.686