(20 nodes) (2010) Evolution of developmental regulation in the vertebrate FgfD subfamily. network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EN2	Homeobox protein engrailed-like. (262 aa)
	PAX8	Paired box 8. (458 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	FBXW11	F-box and WD repeat domain containing 11. (529 aa)
	TLX1	T cell leukemia homeobox 1. (311 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (99 aa)
	AUP1	AUP1 lipid droplet regulating VLDL assembly factor. (423 aa)
	FGF3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (237 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	PAX5	Paired box 5. (189 aa)
	TLX3	T cell leukemia homeobox 3. (291 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	PCDH1	Protocadherin 1. (1197 aa)
	EN1	Homeobox protein engrailed-like. (271 aa)
	PAX2	Paired box 2. (456 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (249 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AUP1	TLX3	ENSLACP00000012169	ENSLACP00000015096	AUP1 lipid droplet regulating VLDL assembly factor.	T cell leukemia homeobox 3.	0.437
EN1	FGF8	ENSLACP00000019687	ENSLACP00000007843	Homeobox protein engrailed-like.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.590
EN1	PAX2	ENSLACP00000019687	ENSLACP00000019870	Homeobox protein engrailed-like.	Paired box 2.	0.706
EN1	PAX8	ENSLACP00000019687	ENSLACP00000004228	Homeobox protein engrailed-like.	Paired box 8.	0.401
EN2	FGF8	ENSLACP00000001649	ENSLACP00000007843	Homeobox protein engrailed-like.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.584
EN2	PAX2	ENSLACP00000001649	ENSLACP00000019870	Homeobox protein engrailed-like.	Paired box 2.	0.484
EN2	PAX5	ENSLACP00000001649	ENSLACP00000014951	Homeobox protein engrailed-like.	Paired box 5.	0.406
EN2	PAX8	ENSLACP00000001649	ENSLACP00000004228	Homeobox protein engrailed-like.	Paired box 8.	0.447
FBXW11	PCDH1	ENSLACP00000005569	ENSLACP00000018125	F-box and WD repeat domain containing 11.	Protocadherin 1.	0.594
FBXW11	TLX3	ENSLACP00000005569	ENSLACP00000015096	F-box and WD repeat domain containing 11.	T cell leukemia homeobox 3.	0.503
FGF18	FGF19	ENSLACP00000015472	ENSLACP00000014596	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.581
FGF18	FGF20	ENSLACP00000015472	ENSLACP00000014835	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.498
FGF18	FGF22	ENSLACP00000015472	ENSLACP00000011779	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.542
FGF18	FGF23	ENSLACP00000015472	ENSLACP00000020506	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.716
FGF18	FGF3	ENSLACP00000015472	ENSLACP00000013990	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.704
FGF18	FGF4	ENSLACP00000015472	ENSLACP00000014225	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.520
FGF18	FGF8	ENSLACP00000015472	ENSLACP00000007843	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.482
FGF18	IHH	ENSLACP00000015472	ENSLACP00000004851	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.686
FGF19	FGF18	ENSLACP00000014596	ENSLACP00000015472	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.581
FGF19	FGF20	ENSLACP00000014596	ENSLACP00000014835	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.467