(18 nodes) (2010) Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimaging. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102365332	Apolipoprotein Ea. (278 aa)
	H3B1Q1_LATCH	Amino acid transporter. (383 aa)
	SLC1A4	Amino acid transporter. (188 aa)
	SLC1A6	Amino acid transporter. (547 aa)
	SLC1A2	Amino acid transporter. (566 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	CTSB	Cathepsin B; Belongs to the peptidase C1 family. (344 aa)
	SLC1A1	Amino acid transporter. (523 aa)
	H3ACE0_LATCH	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (111 aa)
	SLC1A7	Amino acid transporter. (497 aa)
	SLC1A3	Amino acid transporter. (441 aa)
	LOC102347948	Uncharacterized protein. (290 aa)
	SLC1A5	Amino acid transporter. (565 aa)
	LOC102365550	Uncharacterized protein. (218 aa)
	LOC102345634	Amino acid transporter. (345 aa)
	MELTF	Melanotransferrin; Belongs to the transferrin family. (745 aa)
	CLDN5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (213 aa)
	LOC102358762	Amino acid transporter. (538 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLDN5	LOC102347948	ENSLACP00000017353	ENSLACP00000001081	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.633
CLDN5	LOC102365550	ENSLACP00000017353	ENSLACP00000021954	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.633
H3ACE0_LATCH	LEP	ENSLACP00000007311	ENSLACP00000011398	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.864
H3ACE0_LATCH	LOC102365332	ENSLACP00000007311	ENSLACP00000016337	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Apolipoprotein Ea.	0.542
H3B1Q1_LATCH	SLC1A4	ENSLACP00000015822	ENSLACP00000015774	Amino acid transporter.	Amino acid transporter.	0.951
LEP	H3ACE0_LATCH	ENSLACP00000011398	ENSLACP00000007311	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.864
LOC102345634	SLC1A4	ENSLACP00000020079	ENSLACP00000015774	Amino acid transporter.	Amino acid transporter.	0.949
LOC102347948	CLDN5	ENSLACP00000001081	ENSLACP00000017353	Uncharacterized protein.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.633
LOC102347948	LOC102365550	ENSLACP00000001081	ENSLACP00000021954	Uncharacterized protein.	Uncharacterized protein.	0.901
LOC102365332	H3ACE0_LATCH	ENSLACP00000016337	ENSLACP00000007311	Apolipoprotein Ea.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.542
LOC102365550	CLDN5	ENSLACP00000021954	ENSLACP00000017353	Uncharacterized protein.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.633
LOC102365550	LOC102347948	ENSLACP00000021954	ENSLACP00000001081	Uncharacterized protein.	Uncharacterized protein.	0.901
SLC1A4	H3B1Q1_LATCH	ENSLACP00000015774	ENSLACP00000015822	Amino acid transporter.	Amino acid transporter.	0.951
SLC1A4	LOC102345634	ENSLACP00000015774	ENSLACP00000020079	Amino acid transporter.	Amino acid transporter.	0.949