(30 nodes) (2010) PI3Ks in lymphocyte signaling and development. network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (707 aa)
	BCR	Uncharacterized protein. (1277 aa)
	LOC102358762	Amino acid transporter. (538 aa)
	H3B1Q1_LATCH	Amino acid transporter. (383 aa)
	SLC1A4	Amino acid transporter. (188 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	RRAS2	RAS related 2. (202 aa)
	LCK	Tyrosine-protein kinase. (512 aa)
	SLC1A6	Amino acid transporter. (547 aa)
	SLC1A2	Amino acid transporter. (566 aa)
	SYK	Tyrosine-protein kinase. (616 aa)
	CXCR4	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	FOXO1	Forkhead box O1. (633 aa)
	CTLA4	IG domain-containing protein. (186 aa)
	CXCL12	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
	SLC1A1	Amino acid transporter. (523 aa)
	ZAP70	Tyrosine-protein kinase. (609 aa)
	SRC	Tyrosine-protein kinase. (535 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (404 aa)
	IL10	Interleukin 10. (185 aa)
	RAG2	Recombination activating 2. (522 aa)
	RAG1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1045 aa)
	SLC1A7	Amino acid transporter. (497 aa)
	CD40	TNFR-Cys domain-containing protein. (167 aa)
	SLC1A3	Amino acid transporter. (441 aa)
	SLC1A5	Amino acid transporter. (565 aa)
	LOC102358504	SCY domain-containing protein. (118 aa)
	KLF2	Kruppel-like factor 2a. (388 aa)
	LOC102345634	Amino acid transporter. (345 aa)
	DOCK2	Dedicator of cytokinesis 2; Belongs to the DOCK family. (1830 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCR7	CD40	ENSLACP00000015163	ENSLACP00000004148	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	TNFR-Cys domain-containing protein.	0.561
CCR7	CTLA4	ENSLACP00000015163	ENSLACP00000010132	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	IG domain-containing protein.	0.408
CCR7	CXCL12	ENSLACP00000015163	ENSLACP00000009716	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	0.941
CCR7	CXCR4	ENSLACP00000015163	ENSLACP00000012801	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.835
CCR7	IL10	ENSLACP00000015163	ENSLACP00000005382	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Interleukin 10.	0.573
CCR7	LCK	ENSLACP00000015163	ENSLACP00000014811	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Tyrosine-protein kinase.	0.435
CCR7	LOC102358504	ENSLACP00000015163	ENSLACP00000023507	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	SCY domain-containing protein.	0.943
CCR7	RAG1	ENSLACP00000015163	ENSLACP00000004955	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...]	0.451
CCR7	ZAP70	ENSLACP00000015163	ENSLACP00000008633	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Tyrosine-protein kinase.	0.460
CD40	CCR7	ENSLACP00000004148	ENSLACP00000015163	TNFR-Cys domain-containing protein.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.561
CD40	CTLA4	ENSLACP00000004148	ENSLACP00000010132	TNFR-Cys domain-containing protein.	IG domain-containing protein.	0.755
CD40	CXCR4	ENSLACP00000004148	ENSLACP00000012801	TNFR-Cys domain-containing protein.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.461
CD40	IL10	ENSLACP00000004148	ENSLACP00000005382	TNFR-Cys domain-containing protein.	Interleukin 10.	0.712
CD40	LCK	ENSLACP00000004148	ENSLACP00000014811	TNFR-Cys domain-containing protein.	Tyrosine-protein kinase.	0.434
CD40	ZAP70	ENSLACP00000004148	ENSLACP00000008633	TNFR-Cys domain-containing protein.	Tyrosine-protein kinase.	0.438
CTLA4	CCR7	ENSLACP00000010132	ENSLACP00000015163	IG domain-containing protein.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.408
CTLA4	CD40	ENSLACP00000010132	ENSLACP00000004148	IG domain-containing protein.	TNFR-Cys domain-containing protein.	0.755
CTLA4	IL10	ENSLACP00000010132	ENSLACP00000005382	IG domain-containing protein.	Interleukin 10.	0.699
CTLA4	LCK	ENSLACP00000010132	ENSLACP00000014811	IG domain-containing protein.	Tyrosine-protein kinase.	0.592
CTLA4	SRC	ENSLACP00000010132	ENSLACP00000007324	IG domain-containing protein.	Tyrosine-protein kinase.	0.459