(21 nodes) (2011) Wnt signaling is required for early development of zebrafish swimbladder. network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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Your Input:
	PBX1	PBX homeobox 1. (358 aa)
	FOXA1	Forkhead box A1. (439 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (292 aa)
	H3F3B-2	Histone H3; Belongs to the histone H3 family. (136 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	LOC102358266	Dickkopf WNT signaling pathway inhibitor 1b. (261 aa)
	ACTA2	Uncharacterized protein. (338 aa)
	LEF1	Lymphoid enhancer binding factor 1. (397 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	SOX2	SRY-box transcription factor 2. (315 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1598 aa)
	WNT5B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	AXIN2	Axin 2. (841 aa)
	GATA6	GATA binding protein 6. (503 aa)
	H3F3B	Histone H3; Belongs to the histone H3 family. (136 aa)
	HAS2	Hyaluronan synthase 2. (561 aa)
	LOC102355712	Histone H3; Belongs to the histone H3 family. (129 aa)
	AXIN1	Axin 1. (880 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTA2	H3F3B	ENSLACP00000005571	ENSLACP00000001165	Uncharacterized protein.	Histone H3; Belongs to the histone H3 family.	0.478
ACTA2	H3F3B-2	ENSLACP00000005571	ENSLACP00000015909	Uncharacterized protein.	Histone H3; Belongs to the histone H3 family.	0.473
ACTA2	LOC102355712	ENSLACP00000005571	ENSLACP00000009501	Uncharacterized protein.	Histone H3; Belongs to the histone H3 family.	0.471
AXIN1	AXIN2	ENSLACP00000013211	ENSLACP00000019725	Axin 1.	Axin 2.	0.903
AXIN1	CCND1	ENSLACP00000013211	ENSLACP00000014975	Axin 1.	Cyclin D1; Belongs to the cyclin family.	0.428
AXIN1	LEF1	ENSLACP00000013211	ENSLACP00000005598	Axin 1.	Lymphoid enhancer binding factor 1.	0.541
AXIN1	LOC102358266	ENSLACP00000013211	ENSLACP00000005525	Axin 1.	Dickkopf WNT signaling pathway inhibitor 1b.	0.438
AXIN1	LRP5	ENSLACP00000013211	ENSLACP00000021154	Axin 1.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.768
AXIN1	WNT11	ENSLACP00000013211	ENSLACP00000006775	Axin 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.560
AXIN1	WNT2	ENSLACP00000013211	ENSLACP00000017997	Axin 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.439
AXIN1	WNT5B	ENSLACP00000013211	ENSLACP00000020257	Axin 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.504
AXIN1	WNT7A	ENSLACP00000013211	ENSLACP00000006054	Axin 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.518
AXIN2	AXIN1	ENSLACP00000019725	ENSLACP00000013211	Axin 2.	Axin 1.	0.903
AXIN2	CCND1	ENSLACP00000019725	ENSLACP00000014975	Axin 2.	Cyclin D1; Belongs to the cyclin family.	0.580
AXIN2	IHH	ENSLACP00000019725	ENSLACP00000004851	Axin 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.418
AXIN2	LEF1	ENSLACP00000019725	ENSLACP00000005598	Axin 2.	Lymphoid enhancer binding factor 1.	0.762
AXIN2	LOC102358266	ENSLACP00000019725	ENSLACP00000005525	Axin 2.	Dickkopf WNT signaling pathway inhibitor 1b.	0.623
AXIN2	LRP5	ENSLACP00000019725	ENSLACP00000021154	Axin 2.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.841
AXIN2	WNT2	ENSLACP00000019725	ENSLACP00000017997	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.567
AXIN2	WNT5B	ENSLACP00000019725	ENSLACP00000020257	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.415