(21 nodes) (2013) TCTEX1D4, a novel protein phosphatase 1 interactor: connecting the phosphatase to the microtubule network. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102362951	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (351 aa)
	DYNLRB2	Dynein light chain roadblock. (109 aa)
	TCTEX1D4	Tctex1 domain containing 4. (133 aa)
	DYNLT3	Dynein light chain Tctex-type 3. (117 aa)
	DYNC1I1	Uncharacterized protein. (99 aa)
	DNAL4	Dynein light chain. (106 aa)
	ENG	Endoglin. (674 aa)
	DYNC1LI1	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (502 aa)
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (302 aa)
	DYNLL1	Dynein light chain. (115 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	LOC102352268	Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
	CLDN11	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
	TCTEX1D1	Tctex1 domain containing 1. (191 aa)
	PRKACB	Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (359 aa)
	KIF5B	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (918 aa)
	DYNC1LI2	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (505 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
	ESD	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (282 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDK1	DYNC1LI1	ENSLACP00000022056	ENSLACP00000022099	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.	0.492
CDK1	DYNC1LI2	ENSLACP00000022056	ENSLACP00000007763	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.	0.492
CDK1	DYNLL1	ENSLACP00000022056	ENSLACP00000020737	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	Dynein light chain.	0.790
CDK1	TCTEX1D4	ENSLACP00000022056	ENSLACP00000003600	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	Tctex1 domain containing 4.	0.427
CLDN11	ESD	ENSLACP00000016560	ENSLACP00000005433	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	0.660
CLDN11	TCTEX1D4	ENSLACP00000016560	ENSLACP00000003600	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Tctex1 domain containing 4.	0.522
DNAL4	DYNC1I1	ENSLACP00000000150	ENSLACP00000003010	Dynein light chain.	Uncharacterized protein.	0.900
DNAL4	DYNC1LI1	ENSLACP00000000150	ENSLACP00000022099	Dynein light chain.	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.	0.882
DNAL4	DYNC1LI2	ENSLACP00000000150	ENSLACP00000007763	Dynein light chain.	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.	0.873
DNAL4	DYNLL1	ENSLACP00000000150	ENSLACP00000020737	Dynein light chain.	Dynein light chain.	0.462
DNAL4	DYNLRB2	ENSLACP00000000150	ENSLACP00000004174	Dynein light chain.	Dynein light chain roadblock.	0.980
DNAL4	DYNLT3	ENSLACP00000000150	ENSLACP00000003314	Dynein light chain.	Dynein light chain Tctex-type 3.	0.863
DNAL4	TCTEX1D1	ENSLACP00000000150	ENSLACP00000014714	Dynein light chain.	Tctex1 domain containing 1.	0.852
DNAL4	TCTEX1D4	ENSLACP00000000150	ENSLACP00000003600	Dynein light chain.	Tctex1 domain containing 4.	0.852
DYNC1I1	DNAL4	ENSLACP00000003010	ENSLACP00000000150	Uncharacterized protein.	Dynein light chain.	0.900
DYNC1I1	DYNC1LI1	ENSLACP00000003010	ENSLACP00000022099	Uncharacterized protein.	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.	0.994
DYNC1I1	DYNC1LI2	ENSLACP00000003010	ENSLACP00000007763	Uncharacterized protein.	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.	0.993
DYNC1I1	DYNLL1	ENSLACP00000003010	ENSLACP00000020737	Uncharacterized protein.	Dynein light chain.	0.972
DYNC1I1	DYNLRB2	ENSLACP00000003010	ENSLACP00000004174	Uncharacterized protein.	Dynein light chain roadblock.	0.947
DYNC1I1	DYNLT3	ENSLACP00000003010	ENSLACP00000003314	Uncharacterized protein.	Dynein light chain Tctex-type 3.	0.797