(28 nodes) (2013) Transcriptome profiling reveals Th17-like immune responses induced in zebrafish bath-vaccinated with a live attenuated Vibrio anguillarum. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102362951	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (351 aa)
	LOC102358266	Dickkopf WNT signaling pathway inhibitor 1b. (261 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	BCL6	BCL6 transcription repressor. (728 aa)
	CD40	TNFR-Cys domain-containing protein. (167 aa)
	NFXL1	Nuclear transcription factor, X-box binding like 1. (909 aa)
	IREB2	Iron responsive element binding protein 2. (965 aa)
	CCR6	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (397 aa)
	CREBBP	CREB binding protein. (2411 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1598 aa)
	RORC	RAR related orphan receptor C. (502 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1126 aa)
	RHOA	Uncharacterized protein. (193 aa)
	ITGB7	Integrin beta; Belongs to the integrin beta chain family. (778 aa)
	CDC42	Cell division cycle 42. (156 aa)
	MMP13	Matrix metallopeptidase 13. (467 aa)
	MMP9	Matrix metallopeptidase 9. (682 aa)
	VANGL2	Vang-like protein. (498 aa)
	STAT3	Signal transducer and activator of transcription. (763 aa)
	TFR2	Transferrin receptor 2. (728 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
	MRC1	Mannose receptor C-type 1. (1458 aa)
	LTB4R	Leukotriene B4 receptor; Belongs to the G-protein coupled receptor 1 family. (347 aa)
	ABCB8	ATP binding cassette subfamily B member 8. (716 aa)
	HPX	Uncharacterized protein. (228 aa)
	TFRC	Transferrin receptor. (778 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (487 aa)
	H3ACE0_LATCH	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (111 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCB8	NOS2	ENSLACP00000009643	ENSLACP00000020145	ATP binding cassette subfamily B member 8.	Nitric oxide synthase; Produces nitric oxide (NO).	0.500
BCL6	CD40	ENSLACP00000004810	ENSLACP00000004148	BCL6 transcription repressor.	TNFR-Cys domain-containing protein.	0.431
BCL6	CREBBP	ENSLACP00000004810	ENSLACP00000023096	BCL6 transcription repressor.	CREB binding protein.	0.445
BCL6	NFXL1	ENSLACP00000004810	ENSLACP00000002496	BCL6 transcription repressor.	Nuclear transcription factor, X-box binding like 1.	0.502
BCL6	RBPJ	ENSLACP00000004810	ENSLACP00000008245	BCL6 transcription repressor.	Recombination signal binding protein for immunoglobulin kappa J region.	0.403
CD40	BCL6	ENSLACP00000004148	ENSLACP00000004810	TNFR-Cys domain-containing protein.	BCL6 transcription repressor.	0.431
CDC42	ITGB7	ENSLACP00000018010	ENSLACP00000018691	Cell division cycle 42.	Integrin beta; Belongs to the integrin beta chain family.	0.401
CDC42	MMP9	ENSLACP00000018010	ENSLACP00000014693	Cell division cycle 42.	Matrix metallopeptidase 9.	0.450
CDC42	RHOA	ENSLACP00000018010	ENSLACP00000019259	Cell division cycle 42.	Uncharacterized protein.	0.525
CDC42	TFR2	ENSLACP00000018010	ENSLACP00000013285	Cell division cycle 42.	Transferrin receptor 2.	0.432
CDC42	TFRC	ENSLACP00000018010	ENSLACP00000008904	Cell division cycle 42.	Transferrin receptor.	0.432
CDC42	VANGL2	ENSLACP00000018010	ENSLACP00000014486	Cell division cycle 42.	Vang-like protein.	0.533
CREBBP	BCL6	ENSLACP00000023096	ENSLACP00000004810	CREB binding protein.	BCL6 transcription repressor.	0.445
CREBBP	LOC102362951	ENSLACP00000023096	ENSLACP00000007730	CREB binding protein.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	0.932
CREBBP	RBPJ	ENSLACP00000023096	ENSLACP00000008245	CREB binding protein.	Recombination signal binding protein for immunoglobulin kappa J region.	0.992
CREBBP	STAT3	ENSLACP00000023096	ENSLACP00000013656	CREB binding protein.	Signal transducer and activator of transcription.	0.912
H3ACE0_LATCH	LOC102362951	ENSLACP00000007311	ENSLACP00000007730	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	0.540
H3ACE0_LATCH	MMP9	ENSLACP00000007311	ENSLACP00000014693	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Matrix metallopeptidase 9.	0.514
H3ACE0_LATCH	STAT3	ENSLACP00000007311	ENSLACP00000013656	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Signal transducer and activator of transcription.	0.565
HPX	TFR2	ENSLACP00000009194	ENSLACP00000013285	Uncharacterized protein.	Transferrin receptor 2.	0.420