(30 nodes) (2014) Uptake epithelia behave in a cell-centric and not systems homeostatic manner in response to zinc depletion and supplementation. network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	ARPC5	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (164 aa)
	LOC102364002	Uncharacterized protein. (2285 aa)
	MAPK14	Mitogen-activated protein kinase. (399 aa)
	MED23	Uncharacterized protein. (1277 aa)
	GOT2	Aspartate aminotransferase. (392 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (822 aa)
	SMC1A	Structural maintenance of chromosomes protein. (1234 aa)
	GRIA2	Glutamate ionotropic receptor AMPA type subunit 2; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (242 aa)
	EFNA3	Ephrin-A3b; Belongs to the ephrin family. (186 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (463 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (542 aa)
	CKAP5	Cytoskeleton associated protein 5. (1557 aa)
	SOX9	SRY-box transcription factor 9. (475 aa)
	ARG2	Arginase. (363 aa)
	BMP7	Bone morphogenetic protein 7. (425 aa)
	MTOR	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)
	H3B8U3_LATCH	Serine/threonine-protein kinase TOR. (1418 aa)
	RBBP4	RB binding protein 4, chromatin remodeling factor. (464 aa)
	ALAS2	5-aminolevulinate synthase. (615 aa)
	BLMH	Bleomycin hydrolase; Belongs to the peptidase C1 family. (454 aa)
	ELMO1	Engulfment and cell motility 1. (732 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
	SMC3	Structural maintenance of chromosomes protein. (1222 aa)
	HDAC3	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
	GLDC	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (914 aa)
	TNKS	Poly [ADP-ribose] polymerase. (1233 aa)
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (854 aa)
	CAPNS1	Calpain small subunit 1. (269 aa)
	ATM	ATM serine/threonine kinase. (2375 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALAS2	GLDC	ENSLACP00000016314	ENSLACP00000010100	5-aminolevulinate synthase.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.929
ALAS2	SHMT2	ENSLACP00000016314	ENSLACP00000021709	5-aminolevulinate synthase.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.924
ARG2	GLDC	ENSLACP00000020265	ENSLACP00000010100	Arginase.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.580
ARG2	GOT2	ENSLACP00000020265	ENSLACP00000001398	Arginase.	Aspartate aminotransferase.	0.431
ARG2	SHMT2	ENSLACP00000020265	ENSLACP00000021709	Arginase.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.469
ATM	H3B8U3_LATCH	ENSLACP00000005407	ENSLACP00000018314	ATM serine/threonine kinase.	Serine/threonine-protein kinase TOR.	0.523
ATM	HDAC3	ENSLACP00000005407	ENSLACP00000011092	ATM serine/threonine kinase.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.401
ATM	MTOR	ENSLACP00000005407	ENSLACP00000018843	ATM serine/threonine kinase.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.554
ATM	SMC1A	ENSLACP00000005407	ENSLACP00000000964	ATM serine/threonine kinase.	Structural maintenance of chromosomes protein.	0.460
ATM	SMC3	ENSLACP00000005407	ENSLACP00000012032	ATM serine/threonine kinase.	Structural maintenance of chromosomes protein.	0.601
BLMH	RBBP4	ENSLACP00000015708	ENSLACP00000018242	Bleomycin hydrolase; Belongs to the peptidase C1 family.	RB binding protein 4, chromatin remodeling factor.	0.495
BLMH	TNKS	ENSLACP00000015708	ENSLACP00000009201	Bleomycin hydrolase; Belongs to the peptidase C1 family.	Poly [ADP-ribose] polymerase.	0.419
CKAP5	SMC1A	ENSLACP00000021412	ENSLACP00000000964	Cytoskeleton associated protein 5.	Structural maintenance of chromosomes protein.	0.543
CKAP5	SMC3	ENSLACP00000021412	ENSLACP00000012032	Cytoskeleton associated protein 5.	Structural maintenance of chromosomes protein.	0.415
CKAP5	TNKS	ENSLACP00000021412	ENSLACP00000009201	Cytoskeleton associated protein 5.	Poly [ADP-ribose] polymerase.	0.467
ELMO1	MAP2K4	ENSLACP00000012757	ENSLACP00000023386	Engulfment and cell motility 1.	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	0.408
ELMO1	SHMT2	ENSLACP00000012757	ENSLACP00000021709	Engulfment and cell motility 1.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.498
GLDC	ALAS2	ENSLACP00000010100	ENSLACP00000016314	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	5-aminolevulinate synthase.	0.929
GLDC	ARG2	ENSLACP00000010100	ENSLACP00000020265	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	Arginase.	0.580
GLDC	GOT2	ENSLACP00000010100	ENSLACP00000001398	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	Aspartate aminotransferase.	0.417