(48 nodes) (2014) Do all roads lead to Oct4? the emerging concepts of induced pluripotency. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GATA4	GATA binding protein 4. (402 aa)
	TBX3	T-box transcription factor 3. (713 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
	FGF3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (237 aa)
	STAT3	Signal transducer and activator of transcription. (763 aa)
	FGF13	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (99 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	ZEB2	Zinc finger E-box binding homeobox 2. (1251 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (750 aa)
	PAX1	Paired box 1. (362 aa)
	PDGFRA	Uncharacterized protein. (1094 aa)
	LOC102355712	Histone H3; Belongs to the histone H3 family. (129 aa)
	FGF11	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)
	GMNN	Geminin DNA replication inhibitor. (231 aa)
	SOX7	SRY-box transcription factor 7. (369 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	SOX2	SRY-box transcription factor 2. (315 aa)
	BMP4	Bone morphogenetic protein 4. (460 aa)
	OTX2	Orthodenticle homeobox 2. (308 aa)
	NR5A1	Nuclear receptor subfamily 5 group A member 1. (196 aa)
	KLF2	Kruppel-like factor 2a. (388 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	TFCP2L1	Transcription factor CP2 like 1. (468 aa)
	FGF12	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	FGF14	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (163 aa)
	ESRRB	Estrogen related receptor beta. (174 aa)
	PAX6	Paired box 6. (463 aa)
	SOX17	SRY-box transcription factor 17. (381 aa)
	TET1	Tet methylcytosine dioxygenase 1. (1502 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	H3F3B-2	Histone H3; Belongs to the histone H3 family. (136 aa)
	SALL4	Spalt like transcription factor 4. (1002 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	H3F3B	Histone H3; Belongs to the histone H3 family. (136 aa)
	GATA6	GATA binding protein 6. (503 aa)
	GATA3	GATA binding protein 3. (447 aa)
	KLF4	Kruppel like factor 4. (429 aa)
	H3A2B0_LATCH	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	SALL1	Spalt like transcription factor 1. (1306 aa)
	SOX1	SRY-box transcription factor 1. (342 aa)
	LOC102356182	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
	CEBPA	CCAAT/enhancer-binding protein. (299 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	FGF1	ENSLACP00000021723	ENSLACP00000015106	Bone morphogenetic protein 4.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.499
BMP4	FGF11	ENSLACP00000021723	ENSLACP00000008965	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.486
BMP4	FGF12	ENSLACP00000021723	ENSLACP00000019646	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.448
BMP4	FGF13	ENSLACP00000021723	ENSLACP00000013157	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.455
BMP4	FGF14	ENSLACP00000021723	ENSLACP00000018511	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.448
BMP4	FGF16	ENSLACP00000021723	ENSLACP00000011423	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.499
BMP4	FGF18	ENSLACP00000021723	ENSLACP00000015472	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.537
BMP4	FGF19	ENSLACP00000021723	ENSLACP00000014596	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.501
BMP4	FGF2	ENSLACP00000021723	ENSLACP00000019200	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.520
BMP4	FGF20	ENSLACP00000021723	ENSLACP00000014835	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.501
BMP4	FGF22	ENSLACP00000021723	ENSLACP00000011779	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.523
BMP4	FGF3	ENSLACP00000021723	ENSLACP00000013990	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.575
BMP4	FGF4	ENSLACP00000021723	ENSLACP00000014225	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.589
BMP4	FGF5	ENSLACP00000021723	ENSLACP00000016656	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.529
BMP4	FGF6	ENSLACP00000021723	ENSLACP00000020525	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.485
BMP4	FGF7	ENSLACP00000021723	ENSLACP00000016167	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.507
BMP4	FGF8	ENSLACP00000021723	ENSLACP00000007843	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.642
BMP4	GATA4	ENSLACP00000021723	ENSLACP00000006941	Bone morphogenetic protein 4.	GATA binding protein 4.	0.511
BMP4	GATA6	ENSLACP00000021723	ENSLACP00000002849	Bone morphogenetic protein 4.	GATA binding protein 6.	0.435
BMP4	H3A2B0_LATCH	ENSLACP00000021723	ENSLACP00000003781	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.439