(54 nodes) (2013) The Transcriptomics to Proteomics of Hair Cell Regeneration: Looking for a Hair Cell in a Haystack. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AR	Androgen receptor. (412 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	FOXF1	Forkhead box F1. (381 aa)
	IRS1	Insulin receptor substrate 1. (1076 aa)
	PRDM7	PR/SET domain 7. (233 aa)
	TAOK1	TAO kinase 1. (1003 aa)
	MMP13	Matrix metallopeptidase 13. (467 aa)
	MMP9	Matrix metallopeptidase 9. (682 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1106 aa)
	PRL	Prolactin. (231 aa)
	STAT3	Signal transducer and activator of transcription. (763 aa)
	SNCA	Gamma-synuclein; Belongs to the synuclein family. (103 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (421 aa)
	CKB	Creatine kinase B; Belongs to the ATP:guanido phosphotransferase family. (389 aa)
	COCH	Cochlin. (547 aa)
	SNPH	Syntaphilin. (419 aa)
	GSN	Gelsolin. (757 aa)
	BMP5	Bone morphogenetic protein 5. (131 aa)
	SYT7	Synaptotagmin 7. (286 aa)
	POU4F3	POU domain protein. (337 aa)
	SOCS1	Suppressor of cytokine signaling 1a. (190 aa)
	CDH23	Uncharacterized protein. (641 aa)
	LOC102363509	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (248 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	SYNJ2	Synaptojanin 2. (1075 aa)
	JAK1	Janus kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (613 aa)
	H3ACE0_LATCH	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (111 aa)
	TBX3	T-box transcription factor 3. (713 aa)
	LOC102362960	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (256 aa)
	DROSHA	Drosha ribonuclease III. (1347 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	ATOH1	Atonal bHLH transcription factor 1. (279 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (505 aa)
	KIDINS220	Kinase D interacting substrate 220. (1774 aa)
	NRARP	NOTCH regulated ankyrin repeat protein. (112 aa)
	SNAP25	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
	NOTCH3	Notch receptor 3. (1577 aa)
	GATA3	GATA binding protein 3. (447 aa)
	CRIP2	Cysteine rich protein 2. (232 aa)
	RYK	Receptor like tyrosine kinase. (542 aa)
	FGFR3	Fibroblast growth factor receptor. (778 aa)
	VAMP2	V-SNARE coiled-coil homology domain-containing protein. (119 aa)
	LOC102353790	Uncharacterized protein. (899 aa)
	OTOF	Otoferlin. (1895 aa)
	HES3	Hes family bHLH transcription factor 3. (162 aa)
	CELSR2	Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family. (2952 aa)
	SCAMP1	Secretory carrier-associated membrane protein. (339 aa)
	PAX2	Paired box 2. (456 aa)
	AQP2	Aquaporin 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (277 aa)
	BMP4	Bone morphogenetic protein 4. (460 aa)
	IGFBP2	Insulin like growth factor binding protein 2. (279 aa)
	WNT10A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa)
	STX6	Syntaxin 6; Belongs to the syntaxin family. (265 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (646 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQP2	TAOK1	ENSLACP00000020482	ENSLACP00000015051	Aquaporin 2; Belongs to the MIP/aquaporin (TC 1.A.8) family.	TAO kinase 1.	0.461
AR	H3ACE0_LATCH	ENSLACP00000017054	ENSLACP00000007311	Androgen receptor.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.442
AR	SMAD2	ENSLACP00000017054	ENSLACP00000008339	Androgen receptor.	Mothers against decapentaplegic homolog.	0.436
AR	SNAP25	ENSLACP00000017054	ENSLACP00000004765	Androgen receptor.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.514
AR	STAT3	ENSLACP00000017054	ENSLACP00000013656	Androgen receptor.	Signal transducer and activator of transcription.	0.595
ATOH1	EYA1	ENSLACP00000006193	ENSLACP00000017557	Atonal bHLH transcription factor 1.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.478
ATOH1	POU4F3	ENSLACP00000006193	ENSLACP00000009466	Atonal bHLH transcription factor 1.	POU domain protein.	0.610
BMP4	FOXF1	ENSLACP00000021723	ENSLACP00000016145	Bone morphogenetic protein 4.	Forkhead box F1.	0.514
BMP4	H3ACE0_LATCH	ENSLACP00000021723	ENSLACP00000007311	Bone morphogenetic protein 4.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.428
BMP4	PRL	ENSLACP00000021723	ENSLACP00000014482	Bone morphogenetic protein 4.	Prolactin.	0.450
BMP4	SHH	ENSLACP00000021723	ENSLACP00000013019	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.760
BMP4	SMAD2	ENSLACP00000021723	ENSLACP00000008339	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.582
BMP4	TBX3	ENSLACP00000021723	ENSLACP00000007092	Bone morphogenetic protein 4.	T-box transcription factor 3.	0.477
CELSR2	RYK	ENSLACP00000019745	ENSLACP00000001511	Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family.	Receptor like tyrosine kinase.	0.460
CELSR2	TAOK1	ENSLACP00000019745	ENSLACP00000015051	Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family.	TAO kinase 1.	0.432
CKB	OTOF	ENSLACP00000012686	ENSLACP00000019496	Creatine kinase B; Belongs to the ATP:guanido phosphotransferase family.	Otoferlin.	0.477
CKB	SCAMP1	ENSLACP00000012686	ENSLACP00000019293	Creatine kinase B; Belongs to the ATP:guanido phosphotransferase family.	Secretory carrier-associated membrane protein.	0.536
CKB	SNPH	ENSLACP00000012686	ENSLACP00000011703	Creatine kinase B; Belongs to the ATP:guanido phosphotransferase family.	Syntaphilin.	0.536
CKB	STX6	ENSLACP00000012686	ENSLACP00000017708	Creatine kinase B; Belongs to the ATP:guanido phosphotransferase family.	Syntaxin 6; Belongs to the syntaxin family.	0.503
CKB	SYNJ2	ENSLACP00000012686	ENSLACP00000008266	Creatine kinase B; Belongs to the ATP:guanido phosphotransferase family.	Synaptojanin 2.	0.536