(24 nodes) (2014) Hepcidin antagonists for potential treatments of disorders with hepcidin excess. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BMP4	Bone morphogenetic protein 4. (460 aa)
	USF2	Upstream transcription factor 2, c-fos interacting. (307 aa)
	SMAD7	Mothers against decapentaplegic homolog. (377 aa)
	JAK1	Janus kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (613 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
	PRSS23	Serine protease; Belongs to the peptidase S1B family. (382 aa)
	SMAD4	MH2 domain-containing protein. (412 aa)
	IL6	Uncharacterized protein. (149 aa)
	BMP5	Bone morphogenetic protein 5. (131 aa)
	BMP6	Bone morphogenetic protein 6. (428 aa)
	TFR2	Transferrin receptor 2. (728 aa)
	STAT3	Signal transducer and activator of transcription. (763 aa)
	HJV	Hemojuvelin BMP co-receptor. (404 aa)
	FURIN	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (801 aa)
	LOC102354780	Serine protease; Belongs to the peptidase S1B family. (370 aa)
	PRSS35	Serine protease; Belongs to the peptidase S1B family. (379 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
	LOC102352268	Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
	SOCS3	Suppressor of cytokine signaling 3. (205 aa)
	RGMA	Repulsive guidance molecule BMP co-receptor a. (421 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	RGMB	Repulsive guidance molecule BMP co-receptor b. (459 aa)
	IL6R	Interleukin 6 receptor. (469 aa)
	EPO	Erythropoietin. (179 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	BMP6	ENSLACP00000021723	ENSLACP00000012388	Bone morphogenetic protein 4.	Bone morphogenetic protein 6.	0.671
BMP4	HJV	ENSLACP00000021723	ENSLACP00000013803	Bone morphogenetic protein 4.	Hemojuvelin BMP co-receptor.	0.767
BMP4	SMAD4	ENSLACP00000021723	ENSLACP00000009312	Bone morphogenetic protein 4.	MH2 domain-containing protein.	0.815
BMP4	SMAD7	ENSLACP00000021723	ENSLACP00000006551	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.617
BMP5	RGMA	ENSLACP00000011277	ENSLACP00000019758	Bone morphogenetic protein 5.	Repulsive guidance molecule BMP co-receptor a.	0.449
BMP6	BMP4	ENSLACP00000012388	ENSLACP00000021723	Bone morphogenetic protein 6.	Bone morphogenetic protein 4.	0.671
BMP6	HJV	ENSLACP00000012388	ENSLACP00000013803	Bone morphogenetic protein 6.	Hemojuvelin BMP co-receptor.	0.806
BMP6	RGMA	ENSLACP00000012388	ENSLACP00000019758	Bone morphogenetic protein 6.	Repulsive guidance molecule BMP co-receptor a.	0.489
BMP6	RGMB	ENSLACP00000012388	ENSLACP00000021013	Bone morphogenetic protein 6.	Repulsive guidance molecule BMP co-receptor b.	0.455
BMP6	SMAD4	ENSLACP00000012388	ENSLACP00000009312	Bone morphogenetic protein 6.	MH2 domain-containing protein.	0.582
BMP6	TFR2	ENSLACP00000012388	ENSLACP00000013285	Bone morphogenetic protein 6.	Transferrin receptor 2.	0.433
EPO	TFR2	ENSLACP00000022768	ENSLACP00000013285	Erythropoietin.	Transferrin receptor 2.	0.408
FURIN	LOC102354780	ENSLACP00000017120	ENSLACP00000017185	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Serine protease; Belongs to the peptidase S1B family.	0.515
FURIN	PRSS23	ENSLACP00000017120	ENSLACP00000008582	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Serine protease; Belongs to the peptidase S1B family.	0.515
FURIN	PRSS35	ENSLACP00000017120	ENSLACP00000018479	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Serine protease; Belongs to the peptidase S1B family.	0.518
FURIN	TFR2	ENSLACP00000017120	ENSLACP00000013285	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Transferrin receptor 2.	0.424
FURIN	TGFB1	ENSLACP00000017120	ENSLACP00000020652	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.680
HJV	BMP4	ENSLACP00000013803	ENSLACP00000021723	Hemojuvelin BMP co-receptor.	Bone morphogenetic protein 4.	0.767
HJV	BMP6	ENSLACP00000013803	ENSLACP00000012388	Hemojuvelin BMP co-receptor.	Bone morphogenetic protein 6.	0.806
HJV	SMAD4	ENSLACP00000013803	ENSLACP00000009312	Hemojuvelin BMP co-receptor.	MH2 domain-containing protein.	0.505