(20 nodes) (2014) Adipose tissues and thyroid hormones. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HOXC4	Homeobox C4. (439 aa)
	LOC102346019	C1q domain-containing protein. (226 aa)
	HOXA4	Homeobox A4. (239 aa)
	BMP7	Bone morphogenetic protein 7. (425 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	SCD	Stearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (342 aa)
	PRDM16-2	Si:ch211-263k4.2. (114 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (259 aa)
	TCF21	Transcription factor 21. (179 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (404 aa)
	H3ACE0_LATCH	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (111 aa)
	UCP1	Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
	BMP4	Bone morphogenetic protein 4. (460 aa)
	PRDM16	PR/SET domain 16. (1135 aa)
	TMEM26	Transmembrane protein 26. (288 aa)
	HOXD4	Homeobox D4a. (251 aa)
	CIDEA	Cell death inducing DFFA like effector a. (225 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	HOXB4	Homeobox domain-containing protein. (247 aa)
	TSHR	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (689 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	CIDEA	ENSLACP00000000452	ENSLACP00000003679	Adiponectin, C1Q and collagen domain containing.	Cell death inducing DFFA like effector a.	0.575
ADIPOQ	H3ACE0_LATCH	ENSLACP00000000452	ENSLACP00000007311	Adiponectin, C1Q and collagen domain containing.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.830
ADIPOQ	LEP	ENSLACP00000000452	ENSLACP00000011398	Adiponectin, C1Q and collagen domain containing.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.952
ADIPOQ	LOC102346019	ENSLACP00000000452	ENSLACP00000019134	Adiponectin, C1Q and collagen domain containing.	C1q domain-containing protein.	0.904
ADIPOQ	UCP1	ENSLACP00000000452	ENSLACP00000007314	Adiponectin, C1Q and collagen domain containing.	Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.577
BMP4	BMP7	ENSLACP00000021723	ENSLACP00000019986	Bone morphogenetic protein 4.	Bone morphogenetic protein 7.	0.693
BMP4	H3ACE0_LATCH	ENSLACP00000021723	ENSLACP00000007311	Bone morphogenetic protein 4.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.428
BMP7	BMP4	ENSLACP00000019986	ENSLACP00000021723	Bone morphogenetic protein 7.	Bone morphogenetic protein 4.	0.693
CIDEA	ADIPOQ	ENSLACP00000003679	ENSLACP00000000452	Cell death inducing DFFA like effector a.	Adiponectin, C1Q and collagen domain containing.	0.575
CIDEA	LEP	ENSLACP00000003679	ENSLACP00000011398	Cell death inducing DFFA like effector a.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.527
CIDEA	LOC102346019	ENSLACP00000003679	ENSLACP00000019134	Cell death inducing DFFA like effector a.	C1q domain-containing protein.	0.547
CIDEA	PRDM16	ENSLACP00000003679	ENSLACP00000021648	Cell death inducing DFFA like effector a.	PR/SET domain 16.	0.642
CIDEA	PRDM16-2	ENSLACP00000003679	ENSLACP00000021617	Cell death inducing DFFA like effector a.	Si:ch211-263k4.2.	0.628
CIDEA	TMEM26	ENSLACP00000003679	ENSLACP00000000634	Cell death inducing DFFA like effector a.	Transmembrane protein 26.	0.635
CIDEA	UCP1	ENSLACP00000003679	ENSLACP00000007314	Cell death inducing DFFA like effector a.	Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.659
H3ACE0_LATCH	ADIPOQ	ENSLACP00000007311	ENSLACP00000000452	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Adiponectin, C1Q and collagen domain containing.	0.830
H3ACE0_LATCH	BMP4	ENSLACP00000007311	ENSLACP00000021723	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Bone morphogenetic protein 4.	0.428
H3ACE0_LATCH	LEP	ENSLACP00000007311	ENSLACP00000011398	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.864
H3ACE0_LATCH	LOC102346019	ENSLACP00000007311	ENSLACP00000019134	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	C1q domain-containing protein.	0.765
H3ACE0_LATCH	PCK1	ENSLACP00000007311	ENSLACP00000020448	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Phosphoenolpyruvate carboxykinase 1.	0.426