(9 nodes) (2015) Performance Enhancing Diets and the PRISE Protocol to Optimize Athletic Performance. network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102347712	Thioredoxin; Belongs to the thioredoxin family. (105 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (259 aa)
	TXN2	Thioredoxin 2. (162 aa)
	H3ACE0_LATCH	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (111 aa)
	GYG1	Glycogenin 1. (331 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	LOC102346019	C1q domain-containing protein. (226 aa)
	LOC102348047	Sushi domain-containing protein. (802 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1126 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	H3ACE0_LATCH	ENSLACP00000000452	ENSLACP00000007311	Adiponectin, C1Q and collagen domain containing.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.830
ADIPOQ	LEP	ENSLACP00000000452	ENSLACP00000011398	Adiponectin, C1Q and collagen domain containing.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.952
ADIPOQ	LOC102346019	ENSLACP00000000452	ENSLACP00000019134	Adiponectin, C1Q and collagen domain containing.	C1q domain-containing protein.	0.904
H3ACE0_LATCH	ADIPOQ	ENSLACP00000007311	ENSLACP00000000452	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Adiponectin, C1Q and collagen domain containing.	0.830
H3ACE0_LATCH	LEP	ENSLACP00000007311	ENSLACP00000011398	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.864
H3ACE0_LATCH	LOC102346019	ENSLACP00000007311	ENSLACP00000019134	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	C1q domain-containing protein.	0.765
H3ACE0_LATCH	LOC102347712	ENSLACP00000007311	ENSLACP00000002294	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Thioredoxin; Belongs to the thioredoxin family.	0.622
H3ACE0_LATCH	TXN2	ENSLACP00000007311	ENSLACP00000003526	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Thioredoxin 2.	0.416
LEP	ADIPOQ	ENSLACP00000011398	ENSLACP00000000452	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	Adiponectin, C1Q and collagen domain containing.	0.952
LEP	H3ACE0_LATCH	ENSLACP00000011398	ENSLACP00000007311	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.864
LEP	LOC102346019	ENSLACP00000011398	ENSLACP00000019134	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	C1q domain-containing protein.	0.917
LOC102346019	ADIPOQ	ENSLACP00000019134	ENSLACP00000000452	C1q domain-containing protein.	Adiponectin, C1Q and collagen domain containing.	0.904
LOC102346019	H3ACE0_LATCH	ENSLACP00000019134	ENSLACP00000007311	C1q domain-containing protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.765
LOC102346019	LEP	ENSLACP00000019134	ENSLACP00000011398	C1q domain-containing protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.917
LOC102347712	H3ACE0_LATCH	ENSLACP00000002294	ENSLACP00000007311	Thioredoxin; Belongs to the thioredoxin family.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.622
LOC102347712	TXN2	ENSLACP00000002294	ENSLACP00000003526	Thioredoxin; Belongs to the thioredoxin family.	Thioredoxin 2.	0.969
TXN2	H3ACE0_LATCH	ENSLACP00000003526	ENSLACP00000007311	Thioredoxin 2.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.416
TXN2	LOC102347712	ENSLACP00000003526	ENSLACP00000002294	Thioredoxin 2.	Thioredoxin; Belongs to the thioredoxin family.	0.969