(31 nodes) (2015) Tooth and scale morphogenesis in shark: an alternative process to the mammalian enamel knot system. network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	FGF14	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (163 aa)
	LOC102348739	Homeobox protein. (292 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	H3A2B0_LATCH	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	PITX1	Homeobox protein. (305 aa)
	MSX1	Msh homeobox 1. (256 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	PITX2	Homeobox protein. (314 aa)
	LOC102356182	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	FGF11	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (99 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (421 aa)
	FGF13	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
	FGF3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (237 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	LOC102361544	Muscle segment homeobox 3. (275 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	BMP2	Bone morphogenetic protein 2. (402 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	MSX2	Msh homeobox 2. (254 aa)
	FGF12	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
	BMP7	Bone morphogenetic protein 7. (425 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	BMP4	Bone morphogenetic protein 4. (460 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	BMP4	ENSLACP00000016168	ENSLACP00000021723	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.903
BMP2	BMP7	ENSLACP00000016168	ENSLACP00000019986	Bone morphogenetic protein 2.	Bone morphogenetic protein 7.	0.684
BMP2	FGF1	ENSLACP00000016168	ENSLACP00000015106	Bone morphogenetic protein 2.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.401
BMP2	FGF11	ENSLACP00000016168	ENSLACP00000008965	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.451
BMP2	FGF13	ENSLACP00000016168	ENSLACP00000013157	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.419
BMP2	FGF16	ENSLACP00000016168	ENSLACP00000011423	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.401
BMP2	FGF18	ENSLACP00000016168	ENSLACP00000015472	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.443
BMP2	FGF19	ENSLACP00000016168	ENSLACP00000014596	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.430
BMP2	FGF2	ENSLACP00000016168	ENSLACP00000019200	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.451
BMP2	FGF20	ENSLACP00000016168	ENSLACP00000014835	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.401
BMP2	FGF22	ENSLACP00000016168	ENSLACP00000011779	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.455
BMP2	FGF3	ENSLACP00000016168	ENSLACP00000013990	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.472
BMP2	FGF4	ENSLACP00000016168	ENSLACP00000014225	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.501
BMP2	FGF5	ENSLACP00000016168	ENSLACP00000016656	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.467
BMP2	FGF6	ENSLACP00000016168	ENSLACP00000020525	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.409
BMP2	FGF7	ENSLACP00000016168	ENSLACP00000016167	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.412
BMP2	FGF8	ENSLACP00000016168	ENSLACP00000007843	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.421
BMP2	H3A2B0_LATCH	ENSLACP00000016168	ENSLACP00000003781	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.402
BMP2	IHH	ENSLACP00000016168	ENSLACP00000004851	Bone morphogenetic protein 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.538
BMP2	LOC102356182	ENSLACP00000016168	ENSLACP00000006376	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.508