(23 nodes) (2016) Seasonal immunoregulation in a naturally-occurring vertebrate. network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (286 aa)
	LOC102355483	Toll-like receptor 21. (935 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
	RAG1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1045 aa)
	RAG2	Recombination activating 2. (522 aa)
	SATB1	DNA-binding protein SATB. (792 aa)
	NFKBIZ	NFKB inhibitor zeta. (622 aa)
	ZAP70	Tyrosine-protein kinase. (609 aa)
	ITM2A	Integral membrane protein 2A. (256 aa)
	BNIP3	BCL2 interacting protein 3. (202 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	TBK1	TANK binding kinase 1. (675 aa)
	LOC102365332	Apolipoprotein Ea. (278 aa)
	TRIL	TLR4 interactor with leucine rich repeats. (768 aa)
	TNFRSF21	TNF receptor superfamily member 21. (651 aa)
	YIPF4	Protein YIPF. (242 aa)
	ITGB2	Integrin beta. (776 aa)
	LOC102355189	Toll-like receptor 18; Belongs to the Toll-like receptor family. (797 aa)
	RORC	RAR related orphan receptor C. (502 aa)
	TIRAP	TIR domain containing adaptor protein. (267 aa)
	CD302	C-type lectin domain-containing protein. (178 aa)
	RNF128	Ring finger protein 128. (401 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BNIP3	CD302	ENSLACP00000014880	ENSLACP00000022998	BCL2 interacting protein 3.	C-type lectin domain-containing protein.	0.417
BNIP3	ITM2A	ENSLACP00000014880	ENSLACP00000010807	BCL2 interacting protein 3.	Integral membrane protein 2A.	0.472
CCR7	RAG1	ENSLACP00000015163	ENSLACP00000004955	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...]	0.451
CCR7	ZAP70	ENSLACP00000015163	ENSLACP00000008633	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Tyrosine-protein kinase.	0.460
CD302	BNIP3	ENSLACP00000022998	ENSLACP00000014880	C-type lectin domain-containing protein.	BCL2 interacting protein 3.	0.417
CD302	ITM2A	ENSLACP00000022998	ENSLACP00000010807	C-type lectin domain-containing protein.	Integral membrane protein 2A.	0.674
CD302	NFKBIZ	ENSLACP00000022998	ENSLACP00000007879	C-type lectin domain-containing protein.	NFKB inhibitor zeta.	0.547
CD302	RNF128	ENSLACP00000022998	ENSLACP00000023449	C-type lectin domain-containing protein.	Ring finger protein 128.	0.577
CD302	TNFRSF21	ENSLACP00000022998	ENSLACP00000017955	C-type lectin domain-containing protein.	TNF receptor superfamily member 21.	0.540
CD302	ZAP70	ENSLACP00000022998	ENSLACP00000008633	C-type lectin domain-containing protein.	Tyrosine-protein kinase.	0.446
ITGB2	ZAP70	ENSLACP00000019456	ENSLACP00000008633	Integrin beta.	Tyrosine-protein kinase.	0.477
ITM2A	BNIP3	ENSLACP00000010807	ENSLACP00000014880	Integral membrane protein 2A.	BCL2 interacting protein 3.	0.472
ITM2A	CD302	ENSLACP00000010807	ENSLACP00000022998	Integral membrane protein 2A.	C-type lectin domain-containing protein.	0.674
ITM2A	LOC102365332	ENSLACP00000010807	ENSLACP00000016337	Integral membrane protein 2A.	Apolipoprotein Ea.	0.453
ITM2A	NFKBIZ	ENSLACP00000010807	ENSLACP00000007879	Integral membrane protein 2A.	NFKB inhibitor zeta.	0.540
ITM2A	RNF128	ENSLACP00000010807	ENSLACP00000023449	Integral membrane protein 2A.	Ring finger protein 128.	0.652
ITM2A	TNFRSF21	ENSLACP00000010807	ENSLACP00000017955	Integral membrane protein 2A.	TNF receptor superfamily member 21.	0.573
LOC102355189	MYD88	ENSLACP00000020140	ENSLACP00000019094	Toll-like receptor 18; Belongs to the Toll-like receptor family.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.959
LOC102355189	TIRAP	ENSLACP00000020140	ENSLACP00000020333	Toll-like receptor 18; Belongs to the Toll-like receptor family.	TIR domain containing adaptor protein.	0.955
LOC102355483	MYD88	ENSLACP00000001202	ENSLACP00000019094	Toll-like receptor 21.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.856