STRINGSTRING
BMP4 BMP4 ADAMTS5 ADAMTS5 IRX1 IRX1 LOC102357987 LOC102357987 RUNX2 RUNX2 PRRX1 PRRX1 PIEZO1 PIEZO1 BMP5 BMP5 GDF5 GDF5 SMAD4 SMAD4 SIRT1 SIRT1 HAS2 HAS2 SIRT6 SIRT6 HDAC4 HDAC4 FGF8 FGF8 GDF6 GDF6 FOXC1 FOXC1 GDF7 GDF7 TRPS1 TRPS1 OSR2 OSR2 EDNRA EDNRA FRZB FRZB HAND2 HAND2 IHH IHH TGFBR2 TGFBR2 IRX2 IRX2 BMPR1A BMPR1A DLX5 DLX5 TRPV4 TRPV4 PLCB4 PLCB4 CHRD CHRD MMP13 MMP13 PLCB3 PLCB3 HDAC1 HDAC1 FGF18 FGF18 PIEZO2 PIEZO2 EDN1 EDN1 ACAN ACAN WNT9A WNT9A BARX1 BARX1 EVX1 EVX1 BMP7 BMP7 GNAI3 GNAI3 CUX1 CUX1 NOTCH1 NOTCH1 SOX9 SOX9 ASPN ASPN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP4Bone morphogenetic protein 4. (460 aa)
ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif 5. (519 aa)
IRX1Iroquois homeobox 1. (460 aa)
LOC102357987Uncharacterized protein. (2519 aa)
RUNX2Runt-related transcription factor. (452 aa)
PRRX1Paired related homeobox 1. (247 aa)
PIEZO1Piezo-type mechanosensitive ion channel component. (2125 aa)
BMP5Bone morphogenetic protein 5. (131 aa)
GDF5Growth differentiation factor 5. (501 aa)
SMAD4MH2 domain-containing protein. (412 aa)
SIRT1Sirtuin 1. (729 aa)
HAS2Hyaluronan synthase 2. (561 aa)
SIRT6Sirtuin 6. (375 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1086 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
GDF6Growth differentiation factor 6a. (408 aa)
FOXC1Forkhead box C1. (471 aa)
GDF7Growth differentiation factor 7. (416 aa)
TRPS1Transcriptional repressor GATA binding 1. (1290 aa)
OSR2Odd-skipped related transciption factor 2. (314 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (424 aa)
FRZBFrizzled related protein. (318 aa)
HAND2Heart and neural crest derivatives expressed 2. (210 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
IRX2Iroquois homeobox 2. (463 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
DLX5Distal-less homeobox 5. (290 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (870 aa)
PLCB4Phosphoinositide phospholipase C. (919 aa)
CHRDChordin; Belongs to the chordin family. (948 aa)
MMP13Matrix metallopeptidase 13. (467 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1215 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (484 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
PIEZO2Piezo-type mechanosensitive ion channel component. (2426 aa)
EDN1Endothelin 1. (216 aa)
ACANAggrecan. (1860 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (341 aa)
BARX1BARX homeobox 1. (250 aa)
EVX1Even-skipped homeobox 1. (383 aa)
BMP7Bone morphogenetic protein 7. (425 aa)
GNAI3Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa)
CUX1Homeobox protein cut-like. (1477 aa)
NOTCH1Notch receptor 1. (2494 aa)
SOX9SRY-box transcription factor 9. (475 aa)
ASPNAsporin. (396 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.