(21 nodes) (2016) In Silico Analysis of Gene Expression Network Components Underlying Pigmentation Phenotypes in the Python Identified Evolutionarily Conserved Clusters of Transcription Factor Binding Sites. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EDN1	Endothelin 1. (216 aa)
	FOXD3	Forkhead box D3. (373 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	POU3F2	POU domain protein. (379 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (440 aa)
	RAB38	RAB38b, member of RAS oncogene family. (112 aa)
	LEF1	Lymphoid enhancer binding factor 1. (397 aa)
	MYO5A	Myosin VA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1892 aa)
	SNAI2	Snail family zinc finger 2. (268 aa)
	PAX3	Paired box 3. (488 aa)
	USF1	Upstream transcription factor 1. (293 aa)
	LOC102364515	Uncharacterized protein. (221 aa)
	KIT	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (937 aa)
	LYST	Lysosomal trafficking regulator. (3705 aa)
	DCT	Dopachrome tautomerase. (521 aa)
	SOX10	SRY-box transcription factor 10. (451 aa)
	RAB38-2	RAB38b, member of RAS oncogene family. (79 aa)
	SLC2A9	Solute carrier family 2 member 9; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (526 aa)
	TYR	Tyrosinase. (532 aa)
	SOX9	SRY-box transcription factor 9. (475 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTNNB1	LEF1	ENSLACP00000017209	ENSLACP00000005598	Catenin beta 1.	Lymphoid enhancer binding factor 1.	0.999
CTNNB1	SNAI2	ENSLACP00000017209	ENSLACP00000006099	Catenin beta 1.	Snail family zinc finger 2.	0.420
CTNNB1	SOX10	ENSLACP00000017209	ENSLACP00000004990	Catenin beta 1.	SRY-box transcription factor 10.	0.683
CTNNB1	SOX9	ENSLACP00000017209	ENSLACP00000021343	Catenin beta 1.	SRY-box transcription factor 9.	0.683
DCT	EDNRB	ENSLACP00000011443	ENSLACP00000014962	Dopachrome tautomerase.	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	0.442
DCT	RAB38	ENSLACP00000011443	ENSLACP00000000658	Dopachrome tautomerase.	RAB38b, member of RAS oncogene family.	0.515
DCT	RAB38-2	ENSLACP00000011443	ENSLACP00000014829	Dopachrome tautomerase.	RAB38b, member of RAS oncogene family.	0.412
DCT	SOX10	ENSLACP00000011443	ENSLACP00000004990	Dopachrome tautomerase.	SRY-box transcription factor 10.	0.598
DCT	TYR	ENSLACP00000011443	ENSLACP00000011256	Dopachrome tautomerase.	Tyrosinase.	0.797
EDN1	EDNRB	ENSLACP00000018825	ENSLACP00000014962	Endothelin 1.	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	0.998
EDNRB	DCT	ENSLACP00000014962	ENSLACP00000011443	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	Dopachrome tautomerase.	0.442
EDNRB	EDN1	ENSLACP00000014962	ENSLACP00000018825	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.998
EDNRB	KIT	ENSLACP00000014962	ENSLACP00000004383	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.423
EDNRB	MYO5A	ENSLACP00000014962	ENSLACP00000005945	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	Myosin VA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.400
EDNRB	PAX3	ENSLACP00000014962	ENSLACP00000007147	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	Paired box 3.	0.430
EDNRB	SOX10	ENSLACP00000014962	ENSLACP00000004990	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	SRY-box transcription factor 10.	0.541
EDNRB	TYR	ENSLACP00000014962	ENSLACP00000011256	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	Tyrosinase.	0.645
FOXD3	PAX3	ENSLACP00000017581	ENSLACP00000007147	Forkhead box D3.	Paired box 3.	0.641
FOXD3	SNAI2	ENSLACP00000017581	ENSLACP00000006099	Forkhead box D3.	Snail family zinc finger 2.	0.446
FOXD3	SOX10	ENSLACP00000017581	ENSLACP00000004990	Forkhead box D3.	SRY-box transcription factor 10.	0.695