(4 nodes) (2017) Lens apoptosis in the Astyanax blind cavefish is not triggered by its small size or defects in morphogenesis. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CRYAA	Crystallin, alpha A; Belongs to the small heat shock protein (HSP20) family. (173 aa)
	LOC102348739	Homeobox protein. (292 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (421 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRYAA	LOC102348739	ENSLACP00000019120	ENSLACP00000017785	Crystallin, alpha A; Belongs to the small heat shock protein (HSP20) family.	Homeobox protein.	0.413
IHH	SHH	ENSLACP00000004851	ENSLACP00000013019	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.903
LOC102348739	CRYAA	ENSLACP00000017785	ENSLACP00000019120	Homeobox protein.	Crystallin, alpha A; Belongs to the small heat shock protein (HSP20) family.	0.413
SHH	IHH	ENSLACP00000013019	ENSLACP00000004851	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.903