(16 nodes) (2017) Metabolic Disorder in Chronic Obstructive Pulmonary Disease (COPD) Patients: Towards a Personalized Approach Using Marine Drug Derivatives. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (259 aa)
	MC4R	Melanocortin 4 receptor. (329 aa)
	TMEM18	Transmembrane protein 18. (80 aa)
	CHRNA5	Cholinergic receptor nicotinic alpha 5 subunit. (459 aa)
	CHRNA3	Cholinergic receptor nicotinic beta 4 subunit. (552 aa)
	JUP	Junction plakoglobin. (694 aa)
	H3ACE0_LATCH	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (111 aa)
	IL6	Uncharacterized protein. (149 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (403 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	ADIPOR1	Adiponectin receptor 1. (377 aa)
	STAT3	Signal transducer and activator of transcription. (763 aa)
	LOC102363742	Uncharacterized protein; Belongs to the peptidase C14A family. (394 aa)
	LOC102346019	C1q domain-containing protein. (226 aa)
	ADIPOR2	Adiponectin receptor 2. (372 aa)
	AIM2	HIN-200 domain-containing protein. (205 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	ADIPOR1	ENSLACP00000000452	ENSLACP00000013484	Adiponectin, C1Q and collagen domain containing.	Adiponectin receptor 1.	0.986
ADIPOQ	ADIPOR2	ENSLACP00000000452	ENSLACP00000020177	Adiponectin, C1Q and collagen domain containing.	Adiponectin receptor 2.	0.981
ADIPOQ	H3ACE0_LATCH	ENSLACP00000000452	ENSLACP00000007311	Adiponectin, C1Q and collagen domain containing.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.830
ADIPOQ	IL6	ENSLACP00000000452	ENSLACP00000009318	Adiponectin, C1Q and collagen domain containing.	Uncharacterized protein.	0.767
ADIPOQ	LEP	ENSLACP00000000452	ENSLACP00000011398	Adiponectin, C1Q and collagen domain containing.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.952
ADIPOQ	LOC102346019	ENSLACP00000000452	ENSLACP00000019134	Adiponectin, C1Q and collagen domain containing.	C1q domain-containing protein.	0.904
ADIPOQ	PPARG	ENSLACP00000000452	ENSLACP00000010456	Adiponectin, C1Q and collagen domain containing.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.829
ADIPOR1	ADIPOQ	ENSLACP00000013484	ENSLACP00000000452	Adiponectin receptor 1.	Adiponectin, C1Q and collagen domain containing.	0.986
ADIPOR1	ADIPOR2	ENSLACP00000013484	ENSLACP00000020177	Adiponectin receptor 1.	Adiponectin receptor 2.	0.926
ADIPOR1	H3ACE0_LATCH	ENSLACP00000013484	ENSLACP00000007311	Adiponectin receptor 1.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.496
ADIPOR1	LEP	ENSLACP00000013484	ENSLACP00000011398	Adiponectin receptor 1.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.517
ADIPOR1	LOC102346019	ENSLACP00000013484	ENSLACP00000019134	Adiponectin receptor 1.	C1q domain-containing protein.	0.982
ADIPOR2	ADIPOQ	ENSLACP00000020177	ENSLACP00000000452	Adiponectin receptor 2.	Adiponectin, C1Q and collagen domain containing.	0.981
ADIPOR2	ADIPOR1	ENSLACP00000020177	ENSLACP00000013484	Adiponectin receptor 2.	Adiponectin receptor 1.	0.926
ADIPOR2	H3ACE0_LATCH	ENSLACP00000020177	ENSLACP00000007311	Adiponectin receptor 2.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.432
ADIPOR2	LEP	ENSLACP00000020177	ENSLACP00000011398	Adiponectin receptor 2.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.505
ADIPOR2	LOC102346019	ENSLACP00000020177	ENSLACP00000019134	Adiponectin receptor 2.	C1q domain-containing protein.	0.977
AIM2	LOC102363742	ENSLACP00000021844	ENSLACP00000016224	HIN-200 domain-containing protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.861
CHRNA3	CHRNA5	ENSLACP00000005438	ENSLACP00000003123	Cholinergic receptor nicotinic beta 4 subunit.	Cholinergic receptor nicotinic alpha 5 subunit.	0.681
CHRNA3	TMEM18	ENSLACP00000005438	ENSLACP00000003108	Cholinergic receptor nicotinic beta 4 subunit.	Transmembrane protein 18.	0.503