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H3F3B H3F3B CDH2 CDH2 ETV4 ETV4 SOX9 SOX9 TJP1 TJP1 FGF6 FGF6 FGF12 FGF12 FGF2 FGF2 ETV5 ETV5 WT1 WT1 FGF14 FGF14 WNT4 WNT4 FGF5 FGF5 EMX2 EMX2 FGF7 FGF7 TP53 TP53 H3F3B-2 H3F3B-2 FGF18 FGF18 FGF1 FGF1 DMRT1 DMRT1 FGF20 FGF20 FGF19 FGF19 FGF4 FGF4 FGF3 FGF3 FGF13 FGF13 FGF22 FGF22 FGF16 FGF16 CYP19A1 CYP19A1 AMH AMH LOC102355712 LOC102355712 FGF11 FGF11 FGF8 FGF8 FGFR2 FGFR2 CASP3 CASP3 GATA4 GATA4 LOC102356182 LOC102356182 CDH1 CDH1 H3A2B0_LATCH H3A2B0_LATCH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H3F3BHistone H3; Belongs to the histone H3 family. (136 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (894 aa)
ETV4ETS variant 4. (452 aa)
SOX9SRY-box transcription factor 9. (475 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1782 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
ETV5ETS variant 5. (523 aa)
WT1WT1 transcription factor. (422 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (163 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
EMX2Empty spiracles homeobox 2. (247 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
H3F3B-2Histone H3; Belongs to the histone H3 family. (136 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
DMRT1Doublesex and mab-3 related transcription factor 1. (370 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (237 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (99 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1. (443 aa)
AMHAnti-Mullerian hormone. (562 aa)
LOC102355712Histone H3; Belongs to the histone H3 family. (129 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
FGFR2Fibroblast growth factor receptor. (810 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (290 aa)
GATA4GATA binding protein 4. (402 aa)
LOC102356182Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
CDH1Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (829 aa)
H3A2B0_LATCHFibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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