(48 nodes) (2017) Sonic Hedgehog Signaling and Development of the Dentition. network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	PTCH2	Patched 2. (1134 aa)
	BMP2	Bone morphogenetic protein 2. (402 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	H3F3B-2	Histone H3; Belongs to the histone H3 family. (136 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (292 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
	FGF3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (237 aa)
	FGF13	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (421 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (99 aa)
	SPR	Uncharacterized protein. (272 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	SUFU	SUFU negative regulator of hedgehog signaling. (422 aa)
	LOC102355712	Histone H3; Belongs to the histone H3 family. (129 aa)
	FGF11	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	SOX2	SRY-box transcription factor 2. (315 aa)
	LOC102356182	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
	LOC102356298	Uncharacterized protein. (236 aa)
	LEF1	Lymphoid enhancer binding factor 1. (397 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	MSX1	Msh homeobox 1. (256 aa)
	GLI3	GLI family zinc finger 3. (1456 aa)
	PTCH1	Patched 1. (1287 aa)
	PITX1	Homeobox protein. (305 aa)
	H3A2B0_LATCH	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (820 aa)
	IFT88	Intraflagellar transport 88. (833 aa)
	H3F3B	Histone H3; Belongs to the histone H3 family. (136 aa)
	GAS1	Growth arrest specific 1. (259 aa)
	BMP4	Bone morphogenetic protein 4. (460 aa)
	GLI1	GLI family zinc finger 1. (1380 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	CDON	Cell adhesion associated, oncogene regulated. (1293 aa)
	FGF12	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	WNT10A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa)
	FGF14	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (163 aa)
	PAX9	Paired box 9. (342 aa)
	NFIC	Nuclear factor I/C. (188 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	HHIP	Hedgehog interacting protein. (687 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	BMP4	ENSLACP00000016168	ENSLACP00000021723	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.903
BMP2	FGF1	ENSLACP00000016168	ENSLACP00000015106	Bone morphogenetic protein 2.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.401
BMP2	FGF11	ENSLACP00000016168	ENSLACP00000008965	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.451
BMP2	FGF13	ENSLACP00000016168	ENSLACP00000013157	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.419
BMP2	FGF16	ENSLACP00000016168	ENSLACP00000011423	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.401
BMP2	FGF18	ENSLACP00000016168	ENSLACP00000015472	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.443
BMP2	FGF19	ENSLACP00000016168	ENSLACP00000014596	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.430
BMP2	FGF2	ENSLACP00000016168	ENSLACP00000019200	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.451
BMP2	FGF20	ENSLACP00000016168	ENSLACP00000014835	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.401
BMP2	FGF22	ENSLACP00000016168	ENSLACP00000011779	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.455
BMP2	FGF3	ENSLACP00000016168	ENSLACP00000013990	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.472
BMP2	FGF4	ENSLACP00000016168	ENSLACP00000014225	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.501
BMP2	FGF5	ENSLACP00000016168	ENSLACP00000016656	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.467
BMP2	FGF6	ENSLACP00000016168	ENSLACP00000020525	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.409
BMP2	FGF7	ENSLACP00000016168	ENSLACP00000016167	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.412
BMP2	FGF8	ENSLACP00000016168	ENSLACP00000007843	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.421
BMP2	H3A2B0_LATCH	ENSLACP00000016168	ENSLACP00000003781	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.402
BMP2	IHH	ENSLACP00000016168	ENSLACP00000004851	Bone morphogenetic protein 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.538
BMP2	LEF1	ENSLACP00000016168	ENSLACP00000005598	Bone morphogenetic protein 2.	Lymphoid enhancer binding factor 1.	0.406
BMP2	LOC102356182	ENSLACP00000016168	ENSLACP00000006376	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.508