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KRT18 KRT18 RPL18A RPL18A F2 F2 STAT2 STAT2 COX2 COX2 COX3 COX3 ND4 ND4 ND5 ND5 CYTB CYTB FLOT2 FLOT2 ORC5 ORC5 C8A C8A CMC4 CMC4 CDK10 CDK10 CCNB3 CCNB3 LOC102355183 LOC102355183 TSC22D3 TSC22D3 LOC102346102 LOC102346102 CP CP ABCB4 ABCB4 ORC3 ORC3 CCNA1 CCNA1 CCNB2 CCNB2 MCM10 MCM10 CCNA2 CCNA2 SGK1 SGK1 RPL10A RPL10A CDK7 CDK7 CDK9 CDK9 RAD51B RAD51B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KRT18Keratin 18b; Belongs to the intermediate filament family. (447 aa)
RPL18A60S ribosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family. (176 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (618 aa)
STAT2Signal transducer and activator of transcription. (765 aa)
COX2Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (230 aa)
COX3Cytochrome c oxidase subunit 3; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (261 aa)
ND4NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (460 aa)
ND5NADH-ubiquinone oxidoreductase chain 5; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (611 aa)
CYTBCytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (380 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (471 aa)
ORC5Origin recognition complex subunit 5. (264 aa)
C8AComplement C8 alpha chain. (581 aa)
CMC4C-X9-C motif containing 4. (72 aa)
CDK10Cyclin dependent kinase 10. (366 aa)
CCNB3Cyclin B3; Belongs to the cyclin family. (416 aa)
LOC102355183Cytochrome c oxidase subunit; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. (86 aa)
TSC22D3TSC22 domain family member 3. (93 aa)
LOC102346102TSC22 domain family, member 3. (139 aa)
CPCeruloplasmin; Belongs to the multicopper oxidase family. (1095 aa)
ABCB4ATP binding cassette subfamily B member 4. (1161 aa)
ORC3Origin recognition complex subunit 3. (720 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (433 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (404 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (878 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (447 aa)
SGK1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (434 aa)
RPL10ARibosomal protein; Belongs to the universal ribosomal protein uL1 family. (176 aa)
CDK7Cyclin dependent kinase 7. (210 aa)
CDK9Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
RAD51BRAD51 paralog B. (250 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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