(29 nodes) (2018) Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimers Disease. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PCBP2	Poly(rC) binding protein 2. (433 aa)
	APLP1	Amyloid beta (A4) precursor-like protein 1. (699 aa)
	GLRX3	Glutaredoxin 3. (332 aa)
	HTT	Huntingtin. (3125 aa)
	FXR2	FMR1 autosomal homolog 2. (599 aa)
	H3ACE0_LATCH	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (111 aa)
	SLC11A1	Solute carrier family 11 member 1. (544 aa)
	TFRC	Transferrin receptor. (778 aa)
	ATP6V0A1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (840 aa)
	NCSTN	Nicastrin. (680 aa)
	LOC102366987	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (572 aa)
	PDHA1	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (400 aa)
	SORL1	Sortilin-related receptor, L(DLR class) A repeats containing. (1410 aa)
	SLC11A2	Solute carrier family 11 member 2. (502 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
	LOC102345670	Sortilin. (809 aa)
	FXR1	FMR1 autosomal homolog 1. (679 aa)
	SLC40A1	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (583 aa)
	ARNT	Aryl hydrocarbon receptor nuclear translocator. (801 aa)
	SORT1	Sortilin. (734 aa)
	ATP13A2	Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1091 aa)
	SDHB	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (285 aa)
	HEPH	Hephaestin; Belongs to the multicopper oxidase family. (1128 aa)
	PSEN2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (458 aa)
	MELTF	Melanotransferrin; Belongs to the transferrin family. (745 aa)
	FTH1	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (177 aa)
	LOC102347946	Transferrin-like domain-containing protein. (362 aa)
	APLP2	Amyloid beta precursor like protein 2. (732 aa)
	BACE1	Beta-secretase 1; Belongs to the peptidase A1 family. (498 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APLP1	BACE1	ENSLACP00000004749	ENSLACP00000020818	Amyloid beta (A4) precursor-like protein 1.	Beta-secretase 1; Belongs to the peptidase A1 family.	0.644
APLP1	HEPH	ENSLACP00000004749	ENSLACP00000018784	Amyloid beta (A4) precursor-like protein 1.	Hephaestin; Belongs to the multicopper oxidase family.	0.402
APLP1	LOC102345670	ENSLACP00000004749	ENSLACP00000022200	Amyloid beta (A4) precursor-like protein 1.	Sortilin.	0.531
APLP1	LOC102347946	ENSLACP00000004749	ENSLACP00000020421	Amyloid beta (A4) precursor-like protein 1.	Transferrin-like domain-containing protein.	0.493
APLP1	LOC102366987	ENSLACP00000004749	ENSLACP00000011600	Amyloid beta (A4) precursor-like protein 1.	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.	0.440
APLP1	NCSTN	ENSLACP00000004749	ENSLACP00000010981	Amyloid beta (A4) precursor-like protein 1.	Nicastrin.	0.732
APLP1	PSEN1	ENSLACP00000004749	ENSLACP00000012775	Amyloid beta (A4) precursor-like protein 1.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.725
APLP1	PSEN2	ENSLACP00000004749	ENSLACP00000019297	Amyloid beta (A4) precursor-like protein 1.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.793
APLP1	SORL1	ENSLACP00000004749	ENSLACP00000012330	Amyloid beta (A4) precursor-like protein 1.	Sortilin-related receptor, L(DLR class) A repeats containing.	0.796
APLP1	SORT1	ENSLACP00000004749	ENSLACP00000017653	Amyloid beta (A4) precursor-like protein 1.	Sortilin.	0.494
APLP2	BACE1	ENSLACP00000020689	ENSLACP00000020818	Amyloid beta precursor like protein 2.	Beta-secretase 1; Belongs to the peptidase A1 family.	0.704
APLP2	LOC102345670	ENSLACP00000020689	ENSLACP00000022200	Amyloid beta precursor like protein 2.	Sortilin.	0.535
APLP2	LOC102347946	ENSLACP00000020689	ENSLACP00000020421	Amyloid beta precursor like protein 2.	Transferrin-like domain-containing protein.	0.493
APLP2	LOC102366987	ENSLACP00000020689	ENSLACP00000011600	Amyloid beta precursor like protein 2.	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.	0.439
APLP2	NCSTN	ENSLACP00000020689	ENSLACP00000010981	Amyloid beta precursor like protein 2.	Nicastrin.	0.867
APLP2	PSEN1	ENSLACP00000020689	ENSLACP00000012775	Amyloid beta precursor like protein 2.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.721
APLP2	PSEN2	ENSLACP00000020689	ENSLACP00000019297	Amyloid beta precursor like protein 2.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.803
APLP2	SORL1	ENSLACP00000020689	ENSLACP00000012330	Amyloid beta precursor like protein 2.	Sortilin-related receptor, L(DLR class) A repeats containing.	0.868
APLP2	SORT1	ENSLACP00000020689	ENSLACP00000017653	Amyloid beta precursor like protein 2.	Sortilin.	0.515
ATP13A2	SLC11A1	ENSLACP00000017948	ENSLACP00000008718	Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.	Solute carrier family 11 member 1.	0.517