(22 nodes) (2018) High-throughput proteomic profiling of the fish liver following bacterial infection. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102360381	Uncharacterized protein. (300 aa)
	GOLPH3	Golgi phosphoprotein 3. (294 aa)
	SCARB2	Scavenger receptor class B member 2; Belongs to the CD36 family. (375 aa)
	LOC102358202	Tyrosine-protein kinase receptor. (838 aa)
	IL10	Interleukin 10. (185 aa)
	JAK2	Tyrosine-protein kinase. (1152 aa)
	PTER	Phosphotriesterase related. (349 aa)
	H3ACE0_LATCH	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (111 aa)
	SRC	Tyrosine-protein kinase. (535 aa)
	TFRC	Transferrin receptor. (778 aa)
	ABCA1	ATP binding cassette subfamily A member 1. (2267 aa)
	LOC102361734	C-type lectin domain-containing protein. (249 aa)
	SIL1	SIL1 nucleotide exchange factor. (468 aa)
	CP	Ceruloplasmin; Belongs to the multicopper oxidase family. (1095 aa)
	LOC102356874	Phosphatidylinositol transfer protein, beta, like. (272 aa)
	INSR	Uncharacterized protein. (270 aa)
	STAT3	Signal transducer and activator of transcription. (763 aa)
	GOLPH3L	Golgi phosphoprotein 3 like. (286 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	HSPA5	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
	CALR3	Calreticulin. (416 aa)
	LOC102351715	Uncharacterized protein. (1426 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALR3	HSPA5	ENSLACP00000020782	ENSLACP00000020775	Calreticulin.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.931
CP	LOC102351715	ENSLACP00000010818	ENSLACP00000022402	Ceruloplasmin; Belongs to the multicopper oxidase family.	Uncharacterized protein.	0.514
GOLPH3	LOC102356874	ENSLACP00000002732	ENSLACP00000011310	Golgi phosphoprotein 3.	Phosphatidylinositol transfer protein, beta, like.	0.668
GOLPH3	LOC102361734	ENSLACP00000002732	ENSLACP00000010756	Golgi phosphoprotein 3.	C-type lectin domain-containing protein.	0.434
GOLPH3	PTER	ENSLACP00000002732	ENSLACP00000007083	Golgi phosphoprotein 3.	Phosphotriesterase related.	0.674
GOLPH3	SIL1	ENSLACP00000002732	ENSLACP00000010773	Golgi phosphoprotein 3.	SIL1 nucleotide exchange factor.	0.549
GOLPH3L	LOC102356874	ENSLACP00000014538	ENSLACP00000011310	Golgi phosphoprotein 3 like.	Phosphatidylinositol transfer protein, beta, like.	0.668
GOLPH3L	LOC102361734	ENSLACP00000014538	ENSLACP00000010756	Golgi phosphoprotein 3 like.	C-type lectin domain-containing protein.	0.434
GOLPH3L	PTER	ENSLACP00000014538	ENSLACP00000007083	Golgi phosphoprotein 3 like.	Phosphotriesterase related.	0.673
GOLPH3L	SIL1	ENSLACP00000014538	ENSLACP00000010773	Golgi phosphoprotein 3 like.	SIL1 nucleotide exchange factor.	0.542
H3ACE0_LATCH	IL10	ENSLACP00000007311	ENSLACP00000005382	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Interleukin 10.	0.617
H3ACE0_LATCH	INSR	ENSLACP00000007311	ENSLACP00000011313	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.805
H3ACE0_LATCH	JAK2	ENSLACP00000007311	ENSLACP00000006953	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tyrosine-protein kinase.	0.507
H3ACE0_LATCH	LOC102358202	ENSLACP00000007311	ENSLACP00000005349	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tyrosine-protein kinase receptor.	0.805
H3ACE0_LATCH	SRC	ENSLACP00000007311	ENSLACP00000007324	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tyrosine-protein kinase.	0.582
H3ACE0_LATCH	STAT3	ENSLACP00000007311	ENSLACP00000013656	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Signal transducer and activator of transcription.	0.565
H3ACE0_LATCH	TGFB1	ENSLACP00000007311	ENSLACP00000020652	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.540
HSPA5	CALR3	ENSLACP00000020775	ENSLACP00000020782	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	Calreticulin.	0.931
HSPA5	LOC102360381	ENSLACP00000020775	ENSLACP00000001920	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	Uncharacterized protein.	0.911
HSPA5	SIL1	ENSLACP00000020775	ENSLACP00000010773	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	SIL1 nucleotide exchange factor.	0.987