STRINGSTRING
TRH TRH CRH CRH LOC102348150 LOC102348150 SIRT3 SIRT3 JAK2 JAK2 STAT1 STAT1 SIRT5 SIRT5 HDAC4 HDAC4 SIRT6 SIRT6 SIRT1 SIRT1 SIRT7 SIRT7 PPARG PPARG H3ALZ2_LATCH H3ALZ2_LATCH GHRH GHRH HDAC3 HDAC3 FOXO1 FOXO1 GSK3B GSK3B STAT3 STAT3 PRL PRL PIP5K1C PIP5K1C HDAC5 HDAC5 SIRT4 SIRT4 STAT2 STAT2 HDAC7 HDAC7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (262 aa)
CRHCorticotropin releasing hormone. (166 aa)
LOC102348150Signal transducer and activator of transcription. (786 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
JAK2Tyrosine-protein kinase. (1152 aa)
STAT1Signal transducer and activator of transcription. (1179 aa)
SIRT5NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (310 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1086 aa)
SIRT6Sirtuin 6. (375 aa)
SIRT1Sirtuin 1. (729 aa)
SIRT7Sirtuin 7. (413 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (403 aa)
H3ALZ2_LATCHUncharacterized protein. (108 aa)
GHRHGrowth hormone releasing hormone. (168 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
FOXO1Forkhead box O1. (633 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
STAT3Signal transducer and activator of transcription. (763 aa)
PRLProlactin. (231 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (646 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1084 aa)
SIRT4NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (315 aa)
STAT2Signal transducer and activator of transcription. (765 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (873 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.