(21 nodes) (2018) New Insights into the Runt Domain of RUNX2 in Melanoma Cell Proliferation and Migration. network (Latimeria chalumnae)

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Your Input:
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (365 aa)
	SOX9	SRY-box transcription factor 9. (475 aa)
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (302 aa)
	HEY1	Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
	STMN1	Stathmin; Belongs to the stathmin family. (144 aa)
	SIRT6	Sirtuin 6. (375 aa)
	SMAD4	MH2 domain-containing protein. (412 aa)
	HDAC6	Histone deacetylase 6. (1113 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (339 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (404 aa)
	GAPDHS	Glyceraldehyde-3-phosphate dehydrogenase. (396 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (478 aa)
	KIT	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (937 aa)
	WWTR1-2	WW domain-containing protein. (159 aa)
	WWTR1	WW domain containing transcription regulator 1. (264 aa)
	HES1	Hes family bHLH transcription factor 1. (269 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	SMAD3	Mothers against decapentaplegic homolog. (358 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (359 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (768 aa)
	RUNX2	Runt-related transcription factor. (452 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	MAPK1	ENSLACP00000005002	ENSLACP00000015867	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.929
AKT1	NRAS	ENSLACP00000005002	ENSLACP00000020975	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	NRAS proto-oncogene, GTPase.	0.405
AKT1	PTEN	ENSLACP00000005002	ENSLACP00000006424	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.757
AKT1	SMAD4	ENSLACP00000005002	ENSLACP00000009312	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	MH2 domain-containing protein.	0.541
AKT1	WWTR1	ENSLACP00000005002	ENSLACP00000000109	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	WW domain containing transcription regulator 1.	0.466
AKT1	WWTR1-2	ENSLACP00000005002	ENSLACP00000004339	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	WW domain-containing protein.	0.466
BRAF	MAPK1	ENSLACP00000012774	ENSLACP00000015867	B-Raf proto-oncogene, serine/threonine kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.661
BRAF	NRAS	ENSLACP00000012774	ENSLACP00000020975	B-Raf proto-oncogene, serine/threonine kinase.	NRAS proto-oncogene, GTPase.	0.919
BRAF	PTEN	ENSLACP00000012774	ENSLACP00000006424	B-Raf proto-oncogene, serine/threonine kinase.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.692
CDK1	MAPK1	ENSLACP00000022056	ENSLACP00000015867	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.418
CDK1	RUNX2	ENSLACP00000022056	ENSLACP00000013109	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	Runt-related transcription factor.	0.414
CDK1	WWTR1	ENSLACP00000022056	ENSLACP00000000109	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	WW domain containing transcription regulator 1.	0.404
CDK1	WWTR1-2	ENSLACP00000022056	ENSLACP00000004339	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	WW domain-containing protein.	0.404
GAPDH	GAPDHS	ENSLACP00000012705	ENSLACP00000005423	Glyceraldehyde-3-phosphate dehydrogenase.	Glyceraldehyde-3-phosphate dehydrogenase.	0.901
GAPDHS	GAPDH	ENSLACP00000005423	ENSLACP00000012705	Glyceraldehyde-3-phosphate dehydrogenase.	Glyceraldehyde-3-phosphate dehydrogenase.	0.901
HDAC6	RUNX2	ENSLACP00000007918	ENSLACP00000013109	Histone deacetylase 6.	Runt-related transcription factor.	0.426
HDAC6	SIRT6	ENSLACP00000007918	ENSLACP00000008822	Histone deacetylase 6.	Sirtuin 6.	0.461
HES1	WWTR1	ENSLACP00000011054	ENSLACP00000000109	Hes family bHLH transcription factor 1.	WW domain containing transcription regulator 1.	0.408
HES1	WWTR1-2	ENSLACP00000011054	ENSLACP00000004339	Hes family bHLH transcription factor 1.	WW domain-containing protein.	0.408
HEY1	HEY2	ENSLACP00000017643	ENSLACP00000006869	Hes related family bHLH transcription factor with YRPW motif 1.	Hes related family bHLH transcription factor with YRPW motif 2.	0.903