STRINGSTRING
RUNX1-2 RUNX1-2 H3F3B-2 H3F3B-2 RAC1 RAC1 PRKACB PRKACB STAT3 STAT3 BRAF BRAF DCT DCT LOC102355712 LOC102355712 H3ADV1_LATCH H3ADV1_LATCH LOC102362951 LOC102362951 STAT1 STAT1 SRC SRC JAK2 JAK2 PTEN PTEN LOC102348367 LOC102348367 MMP21 MMP21 PLK1 PLK1 TGFBR2 TGFBR2 HEXIM1 HEXIM1 TYRP1 TYRP1 H3F3B H3F3B LOC102352006 LOC102352006 NRAS NRAS TRPM1 TRPM1 HIF1A HIF1A THBS1 THBS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RUNX1-2RUNX family transcription factor 1. (242 aa)
H3F3B-2Histone H3; Belongs to the histone H3 family. (136 aa)
RAC1Rac family small GTPase 1. (192 aa)
PRKACBUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
STAT3Signal transducer and activator of transcription. (763 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (768 aa)
DCTDopachrome tautomerase. (521 aa)
LOC102355712Histone H3; Belongs to the histone H3 family. (129 aa)
H3ADV1_LATCHTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (974 aa)
LOC102362951Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (351 aa)
STAT1Signal transducer and activator of transcription. (1179 aa)
SRCTyrosine-protein kinase. (535 aa)
JAK2Tyrosine-protein kinase. (1152 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (404 aa)
LOC102348367ZnMc domain-containing protein; Belongs to the peptidase M10A family. (559 aa)
MMP21Matrix metallopeptidase 21; Belongs to the peptidase M10A family. (620 aa)
PLK1Serine/threonine-protein kinase PLK. (595 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
HEXIM1HEXIM P-TEFb complex subunit 1. (196 aa)
TYRP1Tyrosinase related protein 1. (536 aa)
H3F3BHistone H3; Belongs to the histone H3 family. (136 aa)
LOC102352006Uncharacterized protein. (163 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
TRPM1Transient receptor potential cation channel subfamily M member 1. (1235 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (813 aa)
THBS1Thrombospondin 1. (1170 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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