(14 nodes) (2018) Zebrafish Mutants Carrying Leptin a (lepa) Gene Deficiency Display Obesity, Anxiety, Less Aggression and Fear, and Circadian Rhythm and Color Preference Dysregulation. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CRH	Corticotropin releasing hormone. (166 aa)
	LOC102348150	Signal transducer and activator of transcription. (786 aa)
	STAT1	Signal transducer and activator of transcription. (1179 aa)
	LEPR	Leptin receptor. (1149 aa)
	CKMT2	Creatine kinase, mitochondrial 2; Belongs to the ATP:guanido phosphotransferase family. (419 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	CKB	Creatine kinase B; Belongs to the ATP:guanido phosphotransferase family. (389 aa)
	POMC	Proopiomelanocortin. (255 aa)
	STAT3	Signal transducer and activator of transcription. (763 aa)
	GHRL	Motilin_assoc domain-containing protein. (110 aa)
	CKMT1A	Creatine kinase, mitochondrial 1; Belongs to the ATP:guanido phosphotransferase family. (418 aa)
	STAT2	Signal transducer and activator of transcription. (765 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (249 aa)
	CKM	Creatine kinase, M-type; Belongs to the ATP:guanido phosphotransferase family. (381 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRH	GHRL	ENSLACP00000002936	ENSLACP00000015917	Corticotropin releasing hormone.	Motilin_assoc domain-containing protein.	0.657
CRH	LEP	ENSLACP00000002936	ENSLACP00000011398	Corticotropin releasing hormone.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.552
CRH	LEPR	ENSLACP00000002936	ENSLACP00000008593	Corticotropin releasing hormone.	Leptin receptor.	0.496
CRH	POMC	ENSLACP00000002936	ENSLACP00000013290	Corticotropin releasing hormone.	Proopiomelanocortin.	0.778
CRH	STAT3	ENSLACP00000002936	ENSLACP00000013656	Corticotropin releasing hormone.	Signal transducer and activator of transcription.	0.554
GHRL	CRH	ENSLACP00000015917	ENSLACP00000002936	Motilin_assoc domain-containing protein.	Corticotropin releasing hormone.	0.657
GHRL	LEP	ENSLACP00000015917	ENSLACP00000011398	Motilin_assoc domain-containing protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.967
GHRL	LEPR	ENSLACP00000015917	ENSLACP00000008593	Motilin_assoc domain-containing protein.	Leptin receptor.	0.560
GHRL	POMC	ENSLACP00000015917	ENSLACP00000013290	Motilin_assoc domain-containing protein.	Proopiomelanocortin.	0.789
LEP	CRH	ENSLACP00000011398	ENSLACP00000002936	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	Corticotropin releasing hormone.	0.552
LEP	GHRL	ENSLACP00000011398	ENSLACP00000015917	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	Motilin_assoc domain-containing protein.	0.967
LEP	LEPR	ENSLACP00000011398	ENSLACP00000008593	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	Leptin receptor.	0.936
LEP	LOC102348150	ENSLACP00000011398	ENSLACP00000002957	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	Signal transducer and activator of transcription.	0.532
LEP	POMC	ENSLACP00000011398	ENSLACP00000013290	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	Proopiomelanocortin.	0.808
LEP	STAT1	ENSLACP00000011398	ENSLACP00000007692	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	Signal transducer and activator of transcription.	0.578
LEP	STAT2	ENSLACP00000011398	ENSLACP00000021655	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	Signal transducer and activator of transcription.	0.579
LEP	STAT3	ENSLACP00000011398	ENSLACP00000013656	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	Signal transducer and activator of transcription.	0.726
LEPR	CRH	ENSLACP00000008593	ENSLACP00000002936	Leptin receptor.	Corticotropin releasing hormone.	0.496
LEPR	GHRL	ENSLACP00000008593	ENSLACP00000015917	Leptin receptor.	Motilin_assoc domain-containing protein.	0.560
LEPR	LEP	ENSLACP00000008593	ENSLACP00000011398	Leptin receptor.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.936