STRINGSTRING
DUOX2 DUOX2 PTCH1 PTCH1 H3A2B0_LATCH H3A2B0_LATCH NOTCH3 NOTCH3 FGF14 FGF14 WT1 WT1 FGF2 FGF2 FGF12 FGF12 H3BES6_LATCH H3BES6_LATCH FGF6 FGF6 DHH DHH FGFR4 FGFR4 GLB1L2 GLB1L2 VEGFC VEGFC RBPJ RBPJ FGF11 FGF11 CXCL12 CXCL12 ANGPT2 ANGPT2 FGF16 FGF16 FGF22 FGF22 DACH1 DACH1 CXCR4 CXCR4 ALDH1A2 ALDH1A2 FGF13 FGF13 FGF3 FGF3 LOC102357450 LOC102357450 FGF4 FGF4 GLB1L GLB1L FGF19 FGF19 FGF20 FGF20 FGF1 FGF1 FGFR1 FGFR1 FGF18 FGF18 SCX SCX FGF7 FGF7 DUSP6 DUSP6 JAG1 JAG1 LOC102353790 LOC102353790 FGF5 FGF5 SOD2 SOD2 PDGFB PDGFB TBX18 TBX18 LOC102350793 LOC102350793 FGF8 FGF8 IGF1R IGF1R LOC102356182 LOC102356182 WNT9B WNT9B SEMA3D SEMA3D IHH IHH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DUOX2Dual oxidase 2. (1551 aa)
PTCH1Patched 1. (1287 aa)
H3A2B0_LATCHFibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
NOTCH3Notch receptor 3. (1577 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (163 aa)
WT1WT1 transcription factor. (422 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
H3BES6_LATCHAngiopoietin 2b. (498 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (424 aa)
FGFR4Fibroblast growth factor receptor. (810 aa)
GLB1L2Beta-galactosidase. (639 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (410 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (487 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
ANGPT2Angiopoietin 2. (493 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (99 aa)
DACH1Dachshund family transcription factor 1. (223 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (363 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (497 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (237 aa)
LOC102357450Uncharacterized protein; Belongs to the heat shock protein 70 family. (641 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
GLB1LGalactosidase beta 1 like; Belongs to the glycosyl hydrolase 35 family. (636 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGFR1Fibroblast growth factor receptor. (824 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
SCXScleraxis bHLH transcription factor. (182 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (382 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
LOC102353790Uncharacterized protein. (899 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (223 aa)
PDGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (209 aa)
TBX18T-box transcription factor 18. (568 aa)
LOC102350793Beta-galactosidase. (627 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
IGF1RInsulin like growth factor 1 receptor. (1170 aa)
LOC102356182Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (715 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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