(21 nodes) (2019) Connecting muscle development, birth defects, and evolution: An essential role for muscle connective tissue. network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HOXD11	Homeobox D11. (294 aa)
	EPHA4	EPH receptor A4. (985 aa)
	PAX3	Paired box 3. (488 aa)
	GATA4	GATA binding protein 4. (402 aa)
	OSR1	Odd-skipped related transcription factor 1. (259 aa)
	PITX2	Homeobox protein. (314 aa)
	OSR2	Odd-skipped related transciption factor 2. (314 aa)
	PITX1	Homeobox protein. (305 aa)
	DLX5	Distal-less homeobox 5. (290 aa)
	TBX5	T-box transcription factor 5. (522 aa)
	BMP4	Bone morphogenetic protein 4. (460 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (720 aa)
	LHX2	LIM homeobox 2. (418 aa)
	HOXA10	Homeobox A10. (557 aa)
	EFNA5	Ephrin A5; Belongs to the ephrin family. (185 aa)
	WT1	WT1 transcription factor. (422 aa)
	MYOG	Myogenin. (242 aa)
	TBX4	T-box transcription factor 4. (541 aa)
	SCX	Scleraxis bHLH transcription factor. (182 aa)
	FAT1	FAT atypical cadherin 1. (3389 aa)
	CXCR4	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (363 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	DLX5	ENSLACP00000021723	ENSLACP00000001948	Bone morphogenetic protein 4.	Distal-less homeobox 5.	0.638
BMP4	GATA4	ENSLACP00000021723	ENSLACP00000006941	Bone morphogenetic protein 4.	GATA binding protein 4.	0.511
BMP4	HOXA10	ENSLACP00000021723	ENSLACP00000019765	Bone morphogenetic protein 4.	Homeobox A10.	0.420
BMP4	PITX1	ENSLACP00000021723	ENSLACP00000003851	Bone morphogenetic protein 4.	Homeobox protein.	0.444
BMP4	PITX2	ENSLACP00000021723	ENSLACP00000006331	Bone morphogenetic protein 4.	Homeobox protein.	0.548
BMP4	TBX4	ENSLACP00000021723	ENSLACP00000016704	Bone morphogenetic protein 4.	T-box transcription factor 4.	0.414
BMP4	TBX5	ENSLACP00000021723	ENSLACP00000002614	Bone morphogenetic protein 4.	T-box transcription factor 5.	0.448
CXCR4	HGF	ENSLACP00000012801	ENSLACP00000023353	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.479
DLX5	BMP4	ENSLACP00000001948	ENSLACP00000021723	Distal-less homeobox 5.	Bone morphogenetic protein 4.	0.638
EFNA5	EPHA4	ENSLACP00000018748	ENSLACP00000007550	Ephrin A5; Belongs to the ephrin family.	EPH receptor A4.	0.849
EPHA4	EFNA5	ENSLACP00000007550	ENSLACP00000018748	EPH receptor A4.	Ephrin A5; Belongs to the ephrin family.	0.849
GATA4	BMP4	ENSLACP00000006941	ENSLACP00000021723	GATA binding protein 4.	Bone morphogenetic protein 4.	0.511
GATA4	TBX5	ENSLACP00000006941	ENSLACP00000002614	GATA binding protein 4.	T-box transcription factor 5.	0.524
GATA4	WT1	ENSLACP00000006941	ENSLACP00000018599	GATA binding protein 4.	WT1 transcription factor.	0.714
HGF	CXCR4	ENSLACP00000023353	ENSLACP00000012801	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.479
HOXA10	BMP4	ENSLACP00000019765	ENSLACP00000021723	Homeobox A10.	Bone morphogenetic protein 4.	0.420
HOXA10	HOXD11	ENSLACP00000019765	ENSLACP00000010850	Homeobox A10.	Homeobox D11.	0.468
HOXD11	HOXA10	ENSLACP00000010850	ENSLACP00000019765	Homeobox D11.	Homeobox A10.	0.468
HOXD11	TBX4	ENSLACP00000010850	ENSLACP00000016704	Homeobox D11.	T-box transcription factor 4.	0.429
HOXD11	TBX5	ENSLACP00000010850	ENSLACP00000002614	Homeobox D11.	T-box transcription factor 5.	0.466