(17 nodes) (2019) Transcriptomic analysis of Anabas testudineus and its defensive mechanisms in response to persistent organic pollutants exposure. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	LOC102346260	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (534 aa)
	SQLE	SE domain-containing protein. (506 aa)
	NSDHL	NAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (340 aa)
	DEGS2	Delta 4-desaturase, sphingolipid 2. (322 aa)
	AHR	Aryl hydrocarbon receptor 1a. (868 aa)
	IDO2	Indoleamine 2,3-dioxygenase 1. (425 aa)
	LOC102354271	UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (495 aa)
	UGDH	UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (424 aa)
	HMGCS1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (525 aa)
	ARNT2	Uncharacterized protein. (206 aa)
	HMGCR	3-hydroxy-3-methylglutaryl coenzyme A reductase. (882 aa)
	ARNT2-2	Aryl-hydrocarbon receptor nuclear translocator 2. (430 aa)
	UGT3A2	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (422 aa)
	LOC102357693	Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. (520 aa)
	LOC102362765	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (537 aa)
	NQO2	N-ribosyldihydronicotinamide:quinone reductase 2. (232 aa)
	VDR	Vitamin D receptor. (427 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHR	ARNT2	ENSLACP00000003128	ENSLACP00000010079	Aryl hydrocarbon receptor 1a.	Uncharacterized protein.	0.815
AHR	ARNT2-2	ENSLACP00000003128	ENSLACP00000011352	Aryl hydrocarbon receptor 1a.	Aryl-hydrocarbon receptor nuclear translocator 2.	0.917
AHR	LOC102357693	ENSLACP00000003128	ENSLACP00000015914	Aryl hydrocarbon receptor 1a.	Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family.	0.721
AHR	LOC102362765	ENSLACP00000003128	ENSLACP00000018641	Aryl hydrocarbon receptor 1a.	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family.	0.487
ARNT2	AHR	ENSLACP00000010079	ENSLACP00000003128	Uncharacterized protein.	Aryl hydrocarbon receptor 1a.	0.815
ARNT2	ARNT2-2	ENSLACP00000010079	ENSLACP00000011352	Uncharacterized protein.	Aryl-hydrocarbon receptor nuclear translocator 2.	0.900
ARNT2	LOC102357693	ENSLACP00000010079	ENSLACP00000015914	Uncharacterized protein.	Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family.	0.632
ARNT2	LOC102362765	ENSLACP00000010079	ENSLACP00000018641	Uncharacterized protein.	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family.	0.465
ARNT2	VDR	ENSLACP00000010079	ENSLACP00000023167	Uncharacterized protein.	Vitamin D receptor.	0.470
ARNT2-2	AHR	ENSLACP00000011352	ENSLACP00000003128	Aryl-hydrocarbon receptor nuclear translocator 2.	Aryl hydrocarbon receptor 1a.	0.917
ARNT2-2	ARNT2	ENSLACP00000011352	ENSLACP00000010079	Aryl-hydrocarbon receptor nuclear translocator 2.	Uncharacterized protein.	0.900
ARNT2-2	LOC102357693	ENSLACP00000011352	ENSLACP00000015914	Aryl-hydrocarbon receptor nuclear translocator 2.	Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family.	0.632
ARNT2-2	LOC102362765	ENSLACP00000011352	ENSLACP00000018641	Aryl-hydrocarbon receptor nuclear translocator 2.	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family.	0.465
ARNT2-2	VDR	ENSLACP00000011352	ENSLACP00000023167	Aryl-hydrocarbon receptor nuclear translocator 2.	Vitamin D receptor.	0.470
DEGS2	HMGCR	ENSLACP00000002363	ENSLACP00000010356	Delta 4-desaturase, sphingolipid 2.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.427
DEGS2	HMGCS1	ENSLACP00000002363	ENSLACP00000007791	Delta 4-desaturase, sphingolipid 2.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.430
DEGS2	IDO2	ENSLACP00000002363	ENSLACP00000003333	Delta 4-desaturase, sphingolipid 2.	Indoleamine 2,3-dioxygenase 1.	0.540
DEGS2	LOC102346260	ENSLACP00000002363	ENSLACP00000000599	Delta 4-desaturase, sphingolipid 2.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.503
DEGS2	LOC102354271	ENSLACP00000002363	ENSLACP00000004742	Delta 4-desaturase, sphingolipid 2.	UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.	0.681
DEGS2	LOC102357693	ENSLACP00000002363	ENSLACP00000015914	Delta 4-desaturase, sphingolipid 2.	Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family.	0.400