(26 nodes) (2019) The Role of Growth Hormone on Ovarian Functioning and Ovarian Angiogenesis. network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	JAK2	Tyrosine-protein kinase. (1152 aa)
	STAT2	Signal transducer and activator of transcription. (765 aa)
	NOTCH1	Notch receptor 1. (2494 aa)
	H3B4D3_LATCH	Somatolactin alpha. (235 aa)
	BMP15	Bone morphogenetic protein 15. (394 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1106 aa)
	LOC102357987	Uncharacterized protein. (2519 aa)
	PRL	Prolactin. (231 aa)
	GNS	N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family. (552 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (688 aa)
	STAT3	Signal transducer and activator of transcription. (763 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	H3ALZ2_LATCH	Uncharacterized protein. (108 aa)
	STAR	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	IL6	Uncharacterized protein. (149 aa)
	DLL3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
	STAT1	Signal transducer and activator of transcription. (1179 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (290 aa)
	LIN28B	Lin-28 homolog B. (279 aa)
	SST	Somatostatin. (118 aa)
	KL	Klotho. (1004 aa)
	LOC102348150	Signal transducer and activator of transcription. (786 aa)
	BMPR1B	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	LOC102349296	Uncharacterized protein. (218 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP15	BMPR1B	ENSLACP00000015177	ENSLACP00000001526	Bone morphogenetic protein 15.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.601
BMP15	STAR	ENSLACP00000015177	ENSLACP00000010485	Bone morphogenetic protein 15.	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.	0.520
BMPR1B	BMP15	ENSLACP00000001526	ENSLACP00000015177	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 15.	0.601
BMPR1B	GNS	ENSLACP00000001526	ENSLACP00000014412	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family.	0.423
CASP3	IL6	ENSLACP00000007386	ENSLACP00000009318	Caspase 3; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.699
CASP3	LEP	ENSLACP00000007386	ENSLACP00000011398	Caspase 3; Belongs to the peptidase C14A family.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.435
CASP3	STAT3	ENSLACP00000007386	ENSLACP00000013656	Caspase 3; Belongs to the peptidase C14A family.	Signal transducer and activator of transcription.	0.592
DLL1	DLL3	ENSLACP00000009351	ENSLACP00000008690	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
DLL1	DLL4	ENSLACP00000009351	ENSLACP00000013765	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.937
DLL1	JAG1	ENSLACP00000009351	ENSLACP00000001302	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.524
DLL1	JAG2	ENSLACP00000009351	ENSLACP00000014617	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.417
DLL1	LOC102357987	ENSLACP00000009351	ENSLACP00000014598	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.984
DLL1	NOTCH1	ENSLACP00000009351	ENSLACP00000020474	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.848
DLL3	DLL1	ENSLACP00000008690	ENSLACP00000009351	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
DLL3	DLL4	ENSLACP00000008690	ENSLACP00000013765	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.938
DLL3	JAG1	ENSLACP00000008690	ENSLACP00000001302	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.486
DLL3	LOC102357987	ENSLACP00000008690	ENSLACP00000014598	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.984
DLL3	NOTCH1	ENSLACP00000008690	ENSLACP00000020474	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.848
DLL4	DLL1	ENSLACP00000013765	ENSLACP00000009351	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.937
DLL4	DLL3	ENSLACP00000013765	ENSLACP00000008690	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.938