(35 nodes) (2019) Cardiac Fibroblasts and the Extracellular Matrix in Regenerative and Nonregenerative Hearts. network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	CRYAB	Crystallin alpha B; Belongs to the small heat shock protein (HSP20) family. (173 aa)
	CCN2	Cellular communication network factor 2. (344 aa)
	HAS3	Hyaluronan synthase 3. (550 aa)
	ADAM12	ADAM metallopeptidase domain 12. (389 aa)
	LOC102354291	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (169 aa)
	COL1A2	Collagen type I alpha 2 chain. (1367 aa)
	FBN2	Uncharacterized protein. (2561 aa)
	CILP2	Cartilage intermediate layer protein 2. (1075 aa)
	POSTN	Periostin. (673 aa)
	TCF21	Transcription factor 21. (179 aa)
	LRRC10	Uncharacterized protein. (244 aa)
	ITGA8	Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1048 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
	FGA	Fibrinogen alpha chain. (723 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	FGB	Fibrinogen beta chain. (454 aa)
	HAS2	Hyaluronan synthase 2. (561 aa)
	FBN1	Fibrillin 1. (2872 aa)
	CCN4	Cellular communication network factor 4. (357 aa)
	PDGFRA	Uncharacterized protein. (1094 aa)
	COL1A1	Collagen type I alpha 1 chain. (1486 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (163 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
	MMP9	Matrix metallopeptidase 9. (682 aa)
	HAS1	Hyaluronan synthase 1. (568 aa)
	FBLN1	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (701 aa)
	HAPLN1	Hyaluronan and proteoglycan link protein 1. (356 aa)
	ACAN	Aggrecan. (1860 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
	LOC102352268	Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (270 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	AGRN	Agrin. (1882 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
	COL5A1	Collagen type V alpha 1 chain. (1742 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAN	FBLN1	ENSLACP00000018851	ENSLACP00000017551	Aggrecan.	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.	0.714
ACAN	HAPLN1	ENSLACP00000018851	ENSLACP00000018187	Aggrecan.	Hyaluronan and proteoglycan link protein 1.	0.979
ACAN	MMP9	ENSLACP00000018851	ENSLACP00000014693	Aggrecan.	Matrix metallopeptidase 9.	0.465
ACAN	TGFB1	ENSLACP00000018851	ENSLACP00000020652	Aggrecan.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.467
ACAN	TGFB3	ENSLACP00000018851	ENSLACP00000018912	Aggrecan.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.424
ADAM12	CILP2	ENSLACP00000001775	ENSLACP00000003769	ADAM metallopeptidase domain 12.	Cartilage intermediate layer protein 2.	0.503
CAV1	CAV2	ENSLACP00000014173	ENSLACP00000014086	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.933
CAV1	LOC102354291	ENSLACP00000014173	ENSLACP00000002046	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.564
CAV1	LRRC10	ENSLACP00000014173	ENSLACP00000005680	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Uncharacterized protein.	0.408
CAV2	CAV1	ENSLACP00000014086	ENSLACP00000014173	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.933
CAV2	CAV3	ENSLACP00000014086	ENSLACP00000020888	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.976
CAV2	LOC102354291	ENSLACP00000014086	ENSLACP00000002046	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.982
CAV2	LRRC10	ENSLACP00000014086	ENSLACP00000005680	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Uncharacterized protein.	0.507
CAV3	CAV2	ENSLACP00000020888	ENSLACP00000014086	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.976
CAV3	LOC102354291	ENSLACP00000020888	ENSLACP00000002046	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.572
CAV3	LRRC10	ENSLACP00000020888	ENSLACP00000005680	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Uncharacterized protein.	0.431
CCN2	FBN1	ENSLACP00000000493	ENSLACP00000010136	Cellular communication network factor 2.	Fibrillin 1.	0.467
CCN2	MMP9	ENSLACP00000000493	ENSLACP00000014693	Cellular communication network factor 2.	Matrix metallopeptidase 9.	0.571
CCN2	POSTN	ENSLACP00000000493	ENSLACP00000005531	Cellular communication network factor 2.	Periostin.	0.571
CCN2	SMAD2	ENSLACP00000000493	ENSLACP00000008339	Cellular communication network factor 2.	Mothers against decapentaplegic homolog.	0.491