STRINGSTRING
SP3 SP3 PPARG PPARG PLD1 PLD1 ATF5 ATF5 SUPT5H SUPT5H IGF1R IGF1R GFRA2 GFRA2 TGFB2 TGFB2 PLD2 PLD2 H3ACE0_LATCH H3ACE0_LATCH GDNF GDNF GATA4 GATA4 GFRAL GFRAL EGR1 EGR1 PRKCA PRKCA RET RET ATF4 ATF4 GFRA1 GFRA1 ATF3 ATF3 FOXQ1 FOXQ1 GAS1 GAS1 TK2 TK2 LOC102367223 LOC102367223 RUNX1 RUNX1 LRRC25 LRRC25 TGFB3 TGFB3 LOC102352268 LOC102352268 ELAVL1 ELAVL1 SOX5 SOX5 TGFB1 TGFB1 PGPEP1 PGPEP1 RUNX1-2 RUNX1-2 STAT3 STAT3 KAT2A KAT2A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SP3Sp3 transcription factor. (785 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (403 aa)
PLD1Phospholipase. (1072 aa)
ATF5Activating transcription factor 5. (340 aa)
SUPT5HTranscription elongation factor SPT5. (1081 aa)
IGF1RInsulin like growth factor 1 receptor. (1170 aa)
GFRA2GDNF domain-containing protein. (123 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
PLD2Phospholipase. (913 aa)
H3ACE0_LATCHInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (111 aa)
GDNFGlial cell derived neurotrophic factor. (222 aa)
GATA4GATA binding protein 4. (402 aa)
GFRALGDNF family receptor alpha like. (220 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (505 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (577 aa)
RETRet proto-oncogene; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1090 aa)
ATF4Activating transcription factor 4. (374 aa)
GFRA1Uncharacterized protein. (257 aa)
ATF3Activating transcription factor 3. (179 aa)
FOXQ1Forkhead box Q1. (329 aa)
GAS1Growth arrest specific 1. (259 aa)
TK2Thymidine kinase 2. (233 aa)
LOC102367223TGF_BETA_2 domain-containing protein. (144 aa)
RUNX1Runt domain-containing protein. (191 aa)
LRRC25Uncharacterized protein. (240 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
LOC102352268Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (355 aa)
SOX5SRY-box transcription factor 5. (757 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
PGPEP1Pyroglutamyl-peptidase I. (256 aa)
RUNX1-2RUNX family transcription factor 1. (242 aa)
STAT3Signal transducer and activator of transcription. (763 aa)
KAT2ALysine acetyltransferase 2A. (740 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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