(32 nodes) (2020) Resveratrol Induces Expression of Metabolic and Antioxidant Machinery and Protects Tilapia under Cold Stress. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (359 aa)
	LOC102367099	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (473 aa)
	GPX8	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (173 aa)
	H3B037_LATCH	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (112 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (783 aa)
	SOD2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (223 aa)
	IRS2	Insulin receptor substrate 2. (1069 aa)
	FOXO3	Fork-head domain-containing protein. (661 aa)
	GPX1	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (142 aa)
	GPX3	Glutathione peroxidase 3. (108 aa)
	LOC102362449	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
	TUBA1C	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (463 aa)
	TUBA1B	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (462 aa)
	LOC102347472	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (466 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (552 aa)
	LOC102358202	Tyrosine-protein kinase receptor. (838 aa)
	LOC102345654	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (358 aa)
	UCP2	Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
	LOC102347712	Thioredoxin; Belongs to the thioredoxin family. (105 aa)
	LOC102345731	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
	INSR	Uncharacterized protein. (270 aa)
	SIRT7	Sirtuin 7. (413 aa)
	SIRT1	Sirtuin 1. (729 aa)
	LOC102347483	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (475 aa)
	SIRT6	Sirtuin 6. (375 aa)
	SIRT5	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (310 aa)
	LOC102346946	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
	H3ACE0_LATCH	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (111 aa)
	SIRT3	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
	GAPDHS	Glyceraldehyde-3-phosphate dehydrogenase. (396 aa)
	FOXO1	Forkhead box O1. (633 aa)
	GPX7	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (185 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FOXO1	FOXO3	ENSLACP00000011598	ENSLACP00000018607	Forkhead box O1.	Fork-head domain-containing protein.	0.903
FOXO1	H3ACE0_LATCH	ENSLACP00000011598	ENSLACP00000007311	Forkhead box O1.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.600
FOXO1	IRS2	ENSLACP00000011598	ENSLACP00000017830	Forkhead box O1.	Insulin receptor substrate 2.	0.504
FOXO1	PPARGC1A	ENSLACP00000011598	ENSLACP00000015962	Forkhead box O1.	PPARG coactivator 1 alpha.	0.975
FOXO1	PRKAA1	ENSLACP00000011598	ENSLACP00000003950	Forkhead box O1.	Non-specific serine/threonine protein kinase.	0.793
FOXO1	SIRT1	ENSLACP00000011598	ENSLACP00000009079	Forkhead box O1.	Sirtuin 1.	0.908
FOXO1	SIRT3	ENSLACP00000011598	ENSLACP00000006675	Forkhead box O1.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.824
FOXO1	SIRT5	ENSLACP00000011598	ENSLACP00000008319	Forkhead box O1.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.567
FOXO1	SIRT6	ENSLACP00000011598	ENSLACP00000008822	Forkhead box O1.	Sirtuin 6.	0.616
FOXO1	SOD2	ENSLACP00000011598	ENSLACP00000017629	Forkhead box O1.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.502
FOXO3	FOXO1	ENSLACP00000018607	ENSLACP00000011598	Fork-head domain-containing protein.	Forkhead box O1.	0.903
FOXO3	PPARGC1A	ENSLACP00000018607	ENSLACP00000015962	Fork-head domain-containing protein.	PPARG coactivator 1 alpha.	0.766
FOXO3	PRKAA1	ENSLACP00000018607	ENSLACP00000003950	Fork-head domain-containing protein.	Non-specific serine/threonine protein kinase.	0.794
FOXO3	SIRT1	ENSLACP00000018607	ENSLACP00000009079	Fork-head domain-containing protein.	Sirtuin 1.	0.902
FOXO3	SIRT3	ENSLACP00000018607	ENSLACP00000006675	Fork-head domain-containing protein.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.802
FOXO3	SIRT6	ENSLACP00000018607	ENSLACP00000008822	Fork-head domain-containing protein.	Sirtuin 6.	0.540
FOXO3	SOD2	ENSLACP00000018607	ENSLACP00000017629	Fork-head domain-containing protein.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.502
GAPDH	GAPDHS	ENSLACP00000012705	ENSLACP00000005423	Glyceraldehyde-3-phosphate dehydrogenase.	Glyceraldehyde-3-phosphate dehydrogenase.	0.901
GAPDH	GPX1	ENSLACP00000012705	ENSLACP00000019151	Glyceraldehyde-3-phosphate dehydrogenase.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.474
GAPDH	GPX3	ENSLACP00000012705	ENSLACP00000019363	Glyceraldehyde-3-phosphate dehydrogenase.	Glutathione peroxidase 3.	0.462