(27 nodes) (2020) Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability. network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CCNA1	Cyclin A1; Belongs to the cyclin family. (433 aa)
	PWWP2B	PWWP domain containing 2B. (577 aa)
	CIITA	Class II major histocompatibility complex transactivator. (793 aa)
	AIF1	Allograft inflammatory factor 1. (119 aa)
	LOC102367553	Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
	CCNA2	Cyclin A2; Belongs to the cyclin family. (447 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (822 aa)
	H3F3B	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC102357659	Uncharacterized protein. (518 aa)
	ACSS2	Acyl-CoA synthetase short chain family member 2. (687 aa)
	MXD1	MAX dimerization protein 1. (226 aa)
	HDAC10	Histone deacetylase 10. (677 aa)
	HDAC5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1084 aa)
	BAK1	BCL2 antagonist/killer 1. (239 aa)
	HOXB7	Homeobox B7. (216 aa)
	TET1	Tet methylcytosine dioxygenase 1. (1502 aa)
	H3F3B-2	Histone H3; Belongs to the histone H3 family. (136 aa)
	ZNF541	Uncharacterized protein. (1385 aa)
	RD3	Retinal degeneration 3, GUCY2D regulator. (197 aa)
	OGT	O-linked N-acetylglucosamine (GlcNAc) transferase. (1048 aa)
	DNTTIP1	Deoxynucleotidyltransferase terminal interacting protein 1. (319 aa)
	ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1. (1027 aa)
	ACSS1	Acetyl-coenzyme A synthetase. (645 aa)
	DNMT1	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1273 aa)
	HDAC11	Histone deacetylase 11. (389 aa)
	LOC102355712	Histone H3; Belongs to the histone H3 family. (129 aa)
	MYCN	MYCN proto-oncogene, bHLH transcription factor. (417 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACSS1	ACSS2	ENSLACP00000013884	ENSLACP00000021008	Acetyl-coenzyme A synthetase.	Acyl-CoA synthetase short chain family member 2.	0.903
ACSS1	HDAC11	ENSLACP00000013884	ENSLACP00000010626	Acetyl-coenzyme A synthetase.	Histone deacetylase 11.	0.455
ACSS1	LOC102357659	ENSLACP00000013884	ENSLACP00000021058	Acetyl-coenzyme A synthetase.	Uncharacterized protein.	0.901
ACSS2	ACSS1	ENSLACP00000021008	ENSLACP00000013884	Acyl-CoA synthetase short chain family member 2.	Acetyl-coenzyme A synthetase.	0.903
ACSS2	HDAC11	ENSLACP00000021008	ENSLACP00000010626	Acyl-CoA synthetase short chain family member 2.	Histone deacetylase 11.	0.450
ACSS2	LOC102357659	ENSLACP00000021008	ENSLACP00000021058	Acyl-CoA synthetase short chain family member 2.	Uncharacterized protein.	0.904
ARAP1	DNMT1	ENSLACP00000014420	ENSLACP00000012502	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1.	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.411
ARAP1	DNTTIP1	ENSLACP00000014420	ENSLACP00000021227	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1.	Deoxynucleotidyltransferase terminal interacting protein 1.	0.501
ARAP1	PWWP2B	ENSLACP00000014420	ENSLACP00000005482	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1.	PWWP domain containing 2B.	0.436
ARAP1	ZNF541	ENSLACP00000014420	ENSLACP00000014926	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1.	Uncharacterized protein.	0.499
CCNA1	CCNA2	ENSLACP00000008389	ENSLACP00000001263	Cyclin A1; Belongs to the cyclin family.	Cyclin A2; Belongs to the cyclin family.	0.962
CCNA2	CCNA1	ENSLACP00000001263	ENSLACP00000008389	Cyclin A2; Belongs to the cyclin family.	Cyclin A1; Belongs to the cyclin family.	0.962
DNMT1	ARAP1	ENSLACP00000012502	ENSLACP00000014420	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1.	0.411
DNMT1	H3F3B	ENSLACP00000012502	ENSLACP00000001165	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone H3; Belongs to the histone H3 family.	0.789
DNMT1	H3F3B-2	ENSLACP00000012502	ENSLACP00000015909	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone H3; Belongs to the histone H3 family.	0.772
DNMT1	HDAC10	ENSLACP00000012502	ENSLACP00000018610	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone deacetylase 10.	0.620
DNMT1	HDAC11	ENSLACP00000012502	ENSLACP00000010626	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone deacetylase 11.	0.642
DNMT1	HDAC5	ENSLACP00000012502	ENSLACP00000018356	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.437
DNMT1	LOC102355712	ENSLACP00000012502	ENSLACP00000009501	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone H3; Belongs to the histone H3 family.	0.775
DNMT1	TET1	ENSLACP00000012502	ENSLACP00000016889	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Tet methylcytosine dioxygenase 1.	0.577