(49 nodes) (2020) TMEM79MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis. network (Latimeria chalumnae)

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Your Input:
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
	PXDN	Peroxidasin. (1149 aa)
	FGF3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (237 aa)
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (955 aa)
	FGF13	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (421 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (359 aa)
	NOTUM	Notum, palmitoleoyl-protein carboxylesterase. (506 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (99 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	FGF11	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	LAMP1	Lysosomal associated membrane protein 1. (412 aa)
	LOC102356182	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
	LOC102358266	Dickkopf WNT signaling pathway inhibitor 1b. (261 aa)
	H3A2B0_LATCH	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (820 aa)
	LOC102360381	Uncharacterized protein. (300 aa)
	EEA1	Early endosome antigen 1. (1412 aa)
	CHRD	Chordin; Belongs to the chordin family. (948 aa)
	EN2	Homeobox protein engrailed-like. (262 aa)
	PXDNL	Peroxidasin like. (1276 aa)
	BMP4	Bone morphogenetic protein 4. (460 aa)
	GLI1	GLI family zinc finger 1. (1380 aa)
	OTX2	Orthodenticle homeobox 2. (308 aa)
	FZD9	Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1598 aa)
	CALR3	Calreticulin. (416 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	SNAI1	Snail family transcriptional repressor 1. (257 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
	FGF12	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	LOC102363206	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
	FGF14	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (163 aa)
	RNF43	RING-type domain-containing protein. (626 aa)
	FOXD3	Forkhead box D3. (373 aa)
	ZNRF3	Zinc and ring finger 3. (698 aa)
	USP19	Ubiquitin specific peptidase 19. (1382 aa)
	SIX3	SIX homeobox 3. (291 aa)
	ZNRF3-2	Uncharacterized protein. (79 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	DVL2	Dishevelled segment polarity protein 2. (401 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	FZD1	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (557 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	CHRD	ENSLACP00000021723	ENSLACP00000000821	Bone morphogenetic protein 4.	Chordin; Belongs to the chordin family.	0.977
BMP4	FGF1	ENSLACP00000021723	ENSLACP00000015106	Bone morphogenetic protein 4.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.499
BMP4	FGF11	ENSLACP00000021723	ENSLACP00000008965	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.486
BMP4	FGF12	ENSLACP00000021723	ENSLACP00000019646	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.448
BMP4	FGF13	ENSLACP00000021723	ENSLACP00000013157	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.455
BMP4	FGF14	ENSLACP00000021723	ENSLACP00000018511	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.448
BMP4	FGF16	ENSLACP00000021723	ENSLACP00000011423	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.499
BMP4	FGF18	ENSLACP00000021723	ENSLACP00000015472	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.537
BMP4	FGF19	ENSLACP00000021723	ENSLACP00000014596	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.501
BMP4	FGF2	ENSLACP00000021723	ENSLACP00000019200	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.520
BMP4	FGF20	ENSLACP00000021723	ENSLACP00000014835	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.501
BMP4	FGF22	ENSLACP00000021723	ENSLACP00000011779	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.523
BMP4	FGF3	ENSLACP00000021723	ENSLACP00000013990	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.575
BMP4	FGF4	ENSLACP00000021723	ENSLACP00000014225	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.589
BMP4	FGF5	ENSLACP00000021723	ENSLACP00000016656	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.529
BMP4	FGF6	ENSLACP00000021723	ENSLACP00000020525	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.485
BMP4	FGF7	ENSLACP00000021723	ENSLACP00000016167	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.507
BMP4	FGF8	ENSLACP00000021723	ENSLACP00000007843	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.642
BMP4	GLI1	ENSLACP00000021723	ENSLACP00000021691	Bone morphogenetic protein 4.	GLI family zinc finger 1.	0.465
BMP4	H3A2B0_LATCH	ENSLACP00000021723	ENSLACP00000003781	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.439