(24 nodes) (2020) Treating Senescence like Cancer: Novel Perspectives in Senotherapy of Chronic Diseases. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CXCR4	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (468 aa)
	H3ANL8_LATCH	Fibroblast activation protein, alpha; Belongs to the peptidase S9B family. (755 aa)
	HMGCR	3-hydroxy-3-methylglutaryl coenzyme A reductase. (882 aa)
	LOC102355712	Histone H3; Belongs to the histone H3 family. (129 aa)
	H3F3B	Histone H3; Belongs to the histone H3 family. (136 aa)
	SIRT1	Sirtuin 1. (729 aa)
	H3ADV1_LATCH	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (974 aa)
	H3ACE0_LATCH	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (111 aa)
	LOC102363280	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
	KL	Klotho. (1004 aa)
	CTSD	Cathepsin D; Belongs to the peptidase A1 family. (397 aa)
	LOC102345199	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (115 aa)
	IL6	Uncharacterized protein. (149 aa)
	PLG	Plasminogen; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
	STAB1	Stabilin 1. (2568 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1126 aa)
	MTOR	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)
	H3B8U3_LATCH	Serine/threonine-protein kinase TOR. (1418 aa)
	SOD2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (223 aa)
	LOC102355307	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (410 aa)
	H3F3B-2	Histone H3; Belongs to the histone H3 family. (136 aa)
	MMP9	Matrix metallopeptidase 9. (682 aa)
	LOC102357450	Uncharacterized protein; Belongs to the heat shock protein 70 family. (641 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTSD	CXCR4	ENSLACP00000002925	ENSLACP00000012801	Cathepsin D; Belongs to the peptidase A1 family.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.420
CTSD	H3ACE0_LATCH	ENSLACP00000002925	ENSLACP00000007311	Cathepsin D; Belongs to the peptidase A1 family.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.643
CTSD	LOC102355307	ENSLACP00000002925	ENSLACP00000016742	Cathepsin D; Belongs to the peptidase A1 family.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.901
CXCR4	CTSD	ENSLACP00000012801	ENSLACP00000002925	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	Cathepsin D; Belongs to the peptidase A1 family.	0.420
CXCR4	H3ACE0_LATCH	ENSLACP00000012801	ENSLACP00000007311	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.450
CXCR4	H3ANL8_LATCH	ENSLACP00000012801	ENSLACP00000011239	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	Fibroblast activation protein, alpha; Belongs to the peptidase S9B family.	0.711
CXCR4	IL6	ENSLACP00000012801	ENSLACP00000009318	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.601
CXCR4	LOC102355307	ENSLACP00000012801	ENSLACP00000016742	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.420
CXCR4	MMP9	ENSLACP00000012801	ENSLACP00000014693	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	Matrix metallopeptidase 9.	0.583
H3ACE0_LATCH	CTSD	ENSLACP00000007311	ENSLACP00000002925	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Cathepsin D; Belongs to the peptidase A1 family.	0.643
H3ACE0_LATCH	CXCR4	ENSLACP00000007311	ENSLACP00000012801	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.450
H3ACE0_LATCH	H3ANL8_LATCH	ENSLACP00000007311	ENSLACP00000011239	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Fibroblast activation protein, alpha; Belongs to the peptidase S9B family.	0.645
H3ACE0_LATCH	HMGCR	ENSLACP00000007311	ENSLACP00000010356	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.418
H3ACE0_LATCH	IL6	ENSLACP00000007311	ENSLACP00000009318	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.773
H3ACE0_LATCH	LOC102345199	ENSLACP00000007311	ENSLACP00000001282	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.511
H3ACE0_LATCH	LOC102355307	ENSLACP00000007311	ENSLACP00000016742	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.643
H3ACE0_LATCH	LOC102363280	ENSLACP00000007311	ENSLACP00000005807	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.578
H3ACE0_LATCH	MMP9	ENSLACP00000007311	ENSLACP00000014693	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Matrix metallopeptidase 9.	0.514
H3ACE0_LATCH	PPARA	ENSLACP00000007311	ENSLACP00000012397	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Peroxisome proliferator activated receptor alpha.	0.555
H3ACE0_LATCH	SIRT1	ENSLACP00000007311	ENSLACP00000009079	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Sirtuin 1.	0.688